The Ghost Busters must stop the Fat Man and Rabbit from summoning the ghost of gangster Big Al Caesar, who will help them steal the stuff dreams are made of: the Maltese Monkey.

Dr. Frankenstein returns, seeking the brain of the world's most gullible fool to transplant into his Monster. Enter Eddie Spencer.

The Ghostbusters' assignment is to rid a haunted mansion of the cowardly ghost of Sir Simon de Canterville. But little do they know that master criminal "Mr. C" is after the priceless Canterville diamond worn by Sir Simon.

Hoping to remove the curse of the werewolf from hapless Harry Albert, Gypsy fortuneteller Sophia comes seeking to steal the Baldus Lupus Amulet that Spencer recently unearthed.

The ghostly captain and his sidekick from the Flying Dutchman take up residence in the castle, looking for new crewmen for their ship. And what "empty-headed scalawag" might fit the bill?

The Phantom of Vaudeville and his ventriloquist's dummy return from beyond to settle a score with Slappy, Maxie, and Nijinsky, three vaudevillians who wronged them in the past. Guess which trio gets mistaken for the three troublemakers?

The Ghost Busters become embroiled with Egyptian Queen Forah and her Mummy as they search for the ape-sorcerer Simios, who in turn can bring them to Spen-Zah, possessor of the secret of immortality.

The ghost of a witch reappears to get revenge against the descendant of Edward Spencer, the spell-dissolver in old Salem who brought ruin to witches. Matters become complicated when the ugly witch transforms herself into a seductive beauty who might lure the Ghost Busting Spencer to his doom.

Those ghostriders in the sky are the spirits of Billy the Kid and Belle Starr back to round up a new gang of cattle rustlers. The Ghost Busters disguise themselves as cowboys to get the Dematerializer drop on 'em.

The Ghost Busters may get the bite put on them when Count and Countess Dracula return from the other side in search of a warm-blooded donor.

The ghost of Dr. Jekyll appears, and is bedeviled by his alter ego. But if he can find a dolt with no personality at all, he can neutralize the effects of the personality-splitting formula and rid himself of Hyde forever. Oh, Spencer?

The ghosts of the Red Baron and Sparky return to repair their plane, the Spirit of Icarus, so that they can once more engage their enemies: Lord Smedly Hargroves and his grease monkey, Tracy Holmes-Harrington... who bear a startling resemblance to two of the Ghost Busters.

The ghosts of Erik the Red and Brunhilda return to plant a Viking banner and establish their claim to having discovered America prior to the loathsome Lothar the Hun.

Merlin and jester Gronk are pursued from the Great Beyond by their nemesis Morgan le Fay, who intends to trap them in this era. The Ghost Busters befriend and assist the broken-down magician in his battle with the beautiful sorceress.

Spencer stumbles onto the scene when Dr. Centigrade is searching for a warm-blooded heart to transplant into the Abominable Snowman. Final episode of the series.