Doctor Octopus commits various mysterious crimes in an effort to upgrade his mechanical arms and steal the world's oil supply.

Doctor Doom is mind-controlling world leaders so, at the upcoming United Nations meeting, they will declare him the master of the world.

The Lizard is plotting to turn New York City into a swampland, filled with reptiles under his control.

The Black Cat announces that she plans to steal the Maltese Mouse and challenges Spider-Man to try to stop her.

The Sandman steals a soil sample from Mars from NASA and goes on a crime spree.

Magneto uses a spacecraft to increase his powers and shut off the nation's power supply.

Mysterio opens up a new disco nightclub in town that turns its patrons and anyone else that hears the disco music into his slaves, whom he uses to try to steal a nuclear missile.

Doctor Doom returns to replace the world leaders with robots under his control so they will declare him ruler of the world.

The circus has come to town, and the Ringmaster uses a special gas to rob banks, while making people believe that Spider-Man is the thief.

Norman Osborn escapes from a mental institution on Halloween night, but when the train he is riding in crashes and blows up, he remembers that he is the Green Goblin and threatens to reveal to the world who Spider-Man really is, and seeks revenge on Jameson for publishing stories about his chemical plant being unsafe.

The Triangle of Evil led by Stuntman forces Spider-Man to survive deadly stunts.

Doctor Doom forms a criminal partnership with Goron to pose as humanitarians to gain control of a space craft.

A rodeo show has come to the city, and the Sidewinder tries to steal the gold spurs.

After being hired by J. Jonah Jameson to look for a mascot for the Daily Bugle, Kraven the Hunter comes to the city as a hero when he captures Zabu, the last surviving sabre-tooth tiger. Ka-Zar comes to the city to liberate his animal companion.

A janitor, feeling that his genius is ignored, dons the identity of the Gadgeteer to steal his employer's new device that can shrink anything and uses it to shrink Spider-Man.

Professor Gizmo seeks to reclaim sunken treasure and requires Spider-Man's help to do so.

Doctor Doom secretly uses a laser cannon to create a fault line on New York City and then promises to fix the problem, when in fact he plans to use his laser cannon to create more earthquakes.

Captain America is kidnapped by the Red Skull, who plans to swap minds with him and take over the military. Spider-Man tries to save Captain America.

Freedom fighters from Latveria start an underground movement in New York City, while Doctor Doom orders the United Nations to make him ruler of the world or else he will use his weather control device to cause chaos.

A mad scientist named Dr. Bradley Shaw transforms into a mutant spider when trying to gain Spider-Man's powers from his blood sample.

NASA sends a rocket into space, built by Doctor Doom, unaware that he has attached a device to it that will move the Earth out of orbit, sending it into a new ice age, in an effort to force the United Nations to declare him to be the master of the world. During his fight against Spider-Man, Doctor Doom is accidentally destroyed by his own laser cannon.

Spider-Man catches the relative of the burglar that killed Ben Parker, which leads the Chameleon to discover Spidey's secret identity. He poses as Uncle Ben's spirit and tricks Aunt May into seeing a medium that will give her a necklace that will hypnotize her into trying to kill Spider-Man.

The Vulture has been kidnapping scientists in an effort to gain control of a NASA space probe. Peter goes to see his friend Harry in his apartment, but he's not home. Vulture mistakes Peter as Harry and kidnaps him.

Upon calling a truce with crime lords Silvermane, Hammerhead and Caesar Cicero, the Kingpin shows them a powerful acid developed by Dr. Everett to unite the crime lords in a plot to pull off crimes. The subsequent chemical waste from the new chemical is illegally dumping into the water, causing sickness to Sub-Mariner's cousin, Namorita. He takes her to the nearest doctor Dr. Donald Blake, then begins to wreak havoc on the surface world.

The Kingpin is able to trick Spider-Man into committing a series of crimes.

The Wizard invites Medusa to New York City, where he forces her to steal an electronic device from a military base.