It is Sena's first day of High School. And from now on his school life will be different. Sena has vowed not to be made a gopher like he has been in the past. But its bad luck for Sena after the Football Team Captain, Hiruma catches Sena running away from the Hah Brothers. Will Sena join the team and help the football team make it to the Christmas Bowl?

Sena may be on the Deimon Devilbats football team, but he realizes that he doesn't know anything about the game of Football. Can Sena learn how to play, or will he give up before the Spring season?

Its Sena's first game as EyeShield 21, and he doesn't know what to do. As the Deimon Devilbats lose, Sena also has to make Mamori believe he isn't EyeShield 21, or he won't be able to play for the Deimon Devilbats ever again. Can Sena get the winning touchdown and keep Mamori beliving he's the team manager and not EyeShield 21?

Sena decides that he needs to get away from having Mamori babying him all the time, so he decides to train alongside the football team, much to her objections.

The power of the Ojo White Knights almost overwhelms Sena, but a little pep talk from Kurita boosts his spirits and he begins to run with a new confidence in his teammates.

After watching Deimon score so easily with Eyeshield-21's speed, Ojo's coach sends in Shin to put an end to Eyeshield 21.

With Shin on the field, Oujo retakes the lead and sets the tone for the game. Sena, having suffered the brunt of Shin's tackles, begins to have second thoughts about playing.

Despite Ojo's overwhelming lead, the Devil Bats keep going. Unfortunately, for Ojo, Sakuraba strays onto the field and gets knocked down by EyeShield. Sena scores a small victory for himself, having managed to finally out-run Shin.

While searching for new players, including a Reciever, Sena finds a player named Raimon Tarou, who has great catching skills. But he is too late because Raimon is already trying out for the baseball team.

Sena, feeling very guilty about Sakuraba's injury, goes to see him in the hospital with Monta. Seeing how despondent Sakuraba is, Sena challenges him to be the hero he truly is.

While running some errands for Hiruma, Sena runs into Shin, who team up to stop two theives trying to steal from the Devil Bats. In the end, the two theives turn out to be from the Zokugaku Chameleons.

The big game with Zokugaku starts with Raimon's debut as the team's new wide reciever. Realizing that Deimon's now got two weapons, Habashira decides to target Sena/Eyeshield 21, who is still more than a little frightened of him.

Realizing that Habashira's not nearly as scary as Shin can be, Sena leaves him and the Zokugaku Chameleons in his dust. Deimon wins 48-28

Recruiting new players for the team has been a snap since their win over Zokugaku, but Hiruma devises a test to seperate the men from the boys.

Realizing that Sena's stamina for running is under-developed, Hiruma developes an amusing way to help him work on it. Meanwhile, Mamori begins to suspect that Sena is really Eyeshield-21 and sets out to prove it.

After a day of practice, Kurita decides to take another way home. He chooses to go through a shopping market that's getting ready for a festival. There, three thugs harass two foreign girls, destroy everything, and run away. This causes Kurita to be the main suspect of the debacle. In order to keep the Deimon Football Team from getting kicked out of the tournament for the Christmas Bowl, Kurita decides to withdraw from the team. Now, Sena and the others will have to find a way to prove Kurita's innocence.

Hiruma tries yet another insane method of training the team, while Monta learns the importance of passing routes when the team sees Ojo nearly defeated in the spring tournament final.

After another futile practice, the WTF trio decide to finally quit the team. After hearing some of the Taiyou Sphinx players make fun of them, they challenge to to a fight. After getting brutally beaten, they come back to the team to try and become linemen good enough to take down the Taiyou players.

The Devil Bats turn up at the Taiyou High School to play the Taiyou Sphinx. The Devil Bats are up against a heavier line. After a declaration form the Sphinx quarterback saying that his team will totally destroy the Devil Bats in only 12 plays.

The game between the Deimon Devil Bats and the Taiyou Sphinx continues. The Devil Bats are gaining points as they begin to outsmart the Sphinx's famous Pyramid Line. The first half ends, and Deimon is only one point behind in the score. Monta is disappointed in himself after his performance during the first half, so he vows that he will ""restore his dishonor"" and make a super max catch! However, when the Sphinx decide to put in their cornerback, Kamaguruma, Monta will feel the full force of Kamaguruma's ""chariot bump!""

Monta is having a difficult time trying to get past the Spinxs new weapon againt them. Everytime Monta goes to catch the football, he is met with a BUMP. Monta doesn't give up in his attempt to get the ball. With the support of his team Monta is able to overcome this obstacle and get past the enemy. With this Monta scores a Touchdown putting the Devil Bats back in the game with only 35 seconds to go. Hiruma gives the order for Sena to ram the opponent or does he.

The first half of a 1-hour special. A young girl on roller-blades named Taki Suzuna has come to Deimon High School to expose Eyeshield 21's true identity for a newspaper article. Suzuna challenges Eyeshield 21 to a race. If Eyeshield wins, then she will leave him alone and not reveal his identity. But, if Suzuna wins, then she will interview Eyeshield and reveal his true identity.

The second half of a 1-Hr special. The Devil Bats plan their method of attack for their Japan-US game against the NASA Aliens. The Aliens are a strong team known for their famous ""shuttle pass."" They also have a fast runner by the name of Panther, who moves swiftly with his antigravity legs. However, the coach has limited Panther to being the team's ball-boy. The Aliens arrive in Japan to enjoy the food and practice, but when their coach's cat gets lost, Panther sees his opportunity to play in the upcoming Japan-US game. Panther also meets Sena and looks forward to seeing him on the football field.

The Deimon Devil Bats are playing against the Nasa Aliens. The Nasa Aliens get a jump in the game against the Devil Bats with their very long pass the Shuttle Pass.

Eyeshield wants to compete against Panther-kun that he works overtime to get him on the field but there is a problem the coach of the NASA Aliens benches any player that doesn't follow his instructions or strategy and Panther-kun is one of those benched players. After the second touchdown from Eyeshield the Deimon Devil Bats are two points behind the NASA Aliens. Panther-kun begs the coach to let him into the game to stop Eyeshield and the coach ignores him. And with another shuttle pass the NASA Aliens Extend their lead once again. But again with one of Hiruma tricky strategies the Deimon Devil Bats are able to score a touchdown. Eyeshield is able to intercept a pass giving the ball back to the Devil Bats, and with the Devil Bats are able to score another touchdown. Panther-kun asks the coach again if he can play in the games but this time the whole team is behind Panther-kun and the coach finally allows Panther-kun into the game. Now Eyeshield faces off against Panther-kun.

The Japan-US game between the Devil Bats and the NASA Aliens comes to its climax! It's Eyeshield 21's golden legs vs. Panther's antigravity legs!

Cerberus gets switiched with a girl's doll, which has a diamond hidden in it by two wanted criminals.

When Sena and Monta get lost in America, they end up at a football field where Panther learned to play. Panther's grandmother notices how well they can play, and asks if they could play with their team. As soon as the match is over, a player's wife goes into labor. The doctor is out fishing on the beach, so Sena needs to get him before it becomes too late. Meanwhile, Hiruma finally finds what he is looking for.

Sena and the rest of the team get involved in a beach football tournament as a way to raise cash for their training in America. Along the way, they meet up and join forces with Tetsuma and Kidd of the Seibu team, who also in America to train.

The Devil Bats' Death March begins. They will have to trek from Houston, Texas all the way to Las Vegas, Nevada in 40 days. Meanwhile, in Japan, Panther meets Shin, who exposes Panther's weakness.

It's day 3 of the Death March, and Toganou and Kuroki decide to quit and run away. Juumonji tries to convince them to come back.

Sena accidentally kicks the rock into a motorcycle gang. Knowing that he will have to run the whole Death March again if he loses it, he runs after them, and gets separated from the rest of the team. There, he literally crashes in Suzuna, who is still looking for her missing brother. They go to a stadium where a professional American Football tryout is being held. It turns out that her brother is there, hoping to become a professional. When the tryout starts, Sena goes in, but is overwhelmed by the crowd. Will he be able to survive, and help Suzuna's brother to achieve his dreams?

Sena applies all the training from the death march in the match. When he scores the winning goal, Sena's last opponent declares that he saw a ghost beside Sena as he ran. When the names of those who passed are read out, Suzuna's brother's name is skipped. He didn't make it, and so Sena asks him to become a member of the Deimon Devil Bats. He accepts, and the Taki siblings and Sena leave. Right after that, the announcer says Sena's name...

Yukimitsu collapses during the run. If he does not complete the run, he will be dropped from the team.

The Devil Bats truck gets stuck in a pothole; with one final push together as a team, Deimon overcomes the last obstacle. Arriving in Las Vegas, on the pirate boat outside Treasure Island, Doburoku confronts Sena to see if the ghost move is complete. Sena passes through Doburoku with the new Devil Bat ghost move, and Doburoku realizes Sena's unlimited potential. At the hotel, everyone rests in preparation for the journey home. The next day, Hiruma sells Doburoku's truck and tells him to go to the casino and bet his all on roulette 21#'s on red 21. The money pays off Doburoku's debt and he returns to Japan with the team.

The Devil Bats return to Japan, but Hiruma informs them that Oujo lost to Shinryuuji. Speaking of Oujo, Sakuraba reaches a breaking point and seriously considers his future as a football player.

The Deimon Devil Bats have returned home. Hiruma must decide on the regular players. Everyone but Yukimitsu is chosen. Yukimitsu will continue to be a bench player.

While hiding from a group of television interviewers, Suzuna questions why Sena doesn't tell Mamori who he is. This leads to a quick review of the previous 38 episodes. In Japan this aired as an hour-long special with 40. Sena tells Suzuna that he will tell Mamori his identity when he is truly strong, namely when he defeats his ultimate rival, Shin Seijuuro.

Kurita and the other Devil Bats learn that one loss means their entire dream will end. Once he gets home, Kurita goes into hiding, not wanting to be the cause of the Devil Bats' failure. Can the others convince him to come out?

Deimon are up against Amino, a school where they use medical science to increase their muscle sizes. They are all artificial muscles. Sena follows "idiot" Taki onto the wrong bus and ends up to a faraway place, Nagano. Meanwhile Deimon, without their ace, must defeat Amino. At first the Deimon defensive linemen cannot hold Amino back and have a touchdown scored on them. Then Doburoku brings in a truck and tells them to push it until they remember how to push with their hips instead of just their arms, just like during the Death March. Deimon pushes through the line and Monta catches a ball for a first down.

Chameleon Habashira Rui gives Sena a lift to the stadium on his motorcycle. In the game, Amino decides to target Monta and tackle him on offense and defense. Amino scores another touchdown and Ishimaru and Monta both score touchdowns for Deimon. The current score is 14:12. Sena is launched off the bike and lands in the stadium with a flashy appearance. He reveals his Devil Bat Ghost, a technique where a runner increases his speed and turns so that the opponent cannot predict where the runner will turn, while the linebacker sees a ghostly image where the player seems to have disappeared like smoke.

Monta and Sena are reluctant to recruit the legendary kicker "60 yard Magnum" Musashi back onto the team. Being misled by soccer students who say a person called "MUro SAtoSHI" is Musashi, Monta and Sena try to recruit him into the American Football team. Meanwhile, a player called Sasaki Koutarou, the Bando Spiders' famed "smart" kicker, appears to challenge Musashi. Will Sena and Monta be able to convince Musashi to rejoin the team?

Taki must pass the entrance exam to be able to play for Deimon. Suzuna tells them Taki has failed every single school with American football in Japan (except Deimon which has accepted every student due to their small number of application students, but Natsuhiko left Japan before being accepted). It turns out Taki is indeed an idiot and Suzana leaves in frustration, with Sena following to comfort her. As it turns out, Taki can answer the question if it is somehow related to American Football. Taki does the exam; a bare pass is 200. At night as the marker is marking the sheet when Hiruma's shadow appears behind him. As the marker announces Taki is safe with 203 points, Hiruma's shadow disappears, and the marker also mentions how he feels that he is the one who "made it." Deimon beats the Zokugaku Chameleons in a practice match because of Taki. At the end, the Zokugaku Chameleons are seen carrying their motorcycles on their backs home as their punishment from their manager, Megu Tsuyumine.

Hiruma forbids Sena to use the Devil Bat Ghost until a real game in order to keep spies from getting looks at it. Meanwhile Shin and Ootawara from Oujou have begun practicing in a corporation league, the Shuuei Elephants, to better hone their skills. The freshmen of the Devil Bats have decided to go to the same stadium, Shuuei Stadium, to inspect the next playing field. The Shuuei Elephants and the Samurai Warriors have an important practice match together, but Taki Natsuhiko leads some of the Samurai Warriors' regulars onto the wrong bus to Nagano Hot Springs (again). Due to the Samurai Warriors' lack of players in the match, Komusubi and Monta substitute and play in the corporation league practice match. Sena is determined to play in the match as well but cannot play due to the lack of an eyeshield, but Suzuna manages to find an eyeshield so Sena saves the match when he enters the game. But Shin wants to see Sena's devil-like Ghost Run instead of it being sealed.

Now substituting in a corporation league game, Sena and Shin finally get the rematch they've been waiting so long for. However, Shin is disappointed as Sena refuses to use the Devil Bat Ghost due to his previous orders from Hiruma. The Samurais are losing due to Ootawara and Shin's entrance into the game, and the line cannot withstand Ootawara. The Huh-Huh brothers arrive and see Sena, Monta, and Komusubi playing, so they too join the game. Shin tells Sena that since he finally got the chance to face him, he won't hold back, and that Sena shouldn't either. With the encouragement of Monta, Komusubi, and the Huh-Huh brothers, Sena decides to use the Devil Bat Ghost.

The Devil Bats witness the physical endurance and team bond of the Yuuhi Guts, their next opponents in the tournament. Hiruma says that objectively, the Devil Bats have a 99% chance of winning, but the Yuuhi Guts have a 1% chance of defeating them due to having three years' more experience. The Devil Bats then go to watch Oujou's game against the Sankaku Punks.

Deimon's game against the Guts begins. Hiruma tries to put pressure on them with words about this being their last chance to go to the Christmas Bowl. However, the Guts' coach has replaced the regular players with athletes from other clubs in order to win, and the regulars aren't allowed to play. The Guts intercept the ball near the beginning of the game and score a touchdown and get the extra point, but after seeing them play, Hiruma lowers the Guts' previous 1% chance of winning to 0%.

The Devil Bats meet the captain of the Hashiratani Deers, Yamamoto Onihei. The Devil Bats go watch the Deers game against the Kyoshin Poseidon, in order to see the team that might become their future opponents. However, they are all disappointed to see the veteran Hashitarani Deers lose to the Kyoshin Poseidons.

Sena learns the truth about the "real" Eyeshield 21 from a Poseidon player, Kakei Shun. Discouraged after hearing that he may never catch up to the real eyeshield, Sena learns from Shin that it isn't size that matters, but an unwavering spirit.

Eyeshield 21 enters the Chameleons' locker room and cuts up all their uniforms in the middle of the night. Sena said he did not do it. The Chameleons enter Deimon and try and find Eyeshield 21. They find out the Scorpions were impersonating Eyeshield.

Chamelon and Poseidon start their game. Poseidon has a great advantage because they have tall players. On the other hand the Chameleon team is disunited. Habashira's team gave up halfway through. Habashira tries to encourage them and force his team to win, but fails. In the end Rui confronts Hiruma and cries out through his tears, "WHAT WAS THE DIFFERENCE BETWEEN YOU AND ME!"

The scorpion is playing really dirty. They are also predicting the Devil Bats' every move. Hiruma disappears during the game. Kurita must stay strong to win against those cowards.

At the end of the first quarter Mamori opens the game plan Hiruma gave her, which shows that Hiruma predicted every single thing that happened in the first quarter. At last Hiruma appears. The Devil Bats win the game with the help of Hiruma's Devil plans. Hiruma confirms his new slave after the game.

After being told by Mizumachi from the Poseidons that he is no good at football, Komosubi runs away from him. He thinks that because he is short, he is useless to the Devil Bats. Everyone goes looking for him and they convince him to return home.

Komusubi starts learning sumo. With his special training, he finds a way to overcome the physical difference between himself and Mizumachi and Kakei.

When Monta and Sena are sent to spy on the Poseidons' final practice before the game, they are caught, and Kakei tells Sena that he wants to challenge Eyeshield 21 from the Devil Bats and prove to him that he will never match up to the "real" Eyeshield 21. Sena gets past him using the Devil Bat Ghost, but Hiruma, who had been watching, tells Sena that it was not Kakei's true strength he was running against.

The game against the Kyoshin Poseidons is about to begin. Kakei tells Sena that he'll prove once and for all that he's not qualified to bear the name "Eyeshield 21." Hiruma then states that the taller team won't win, but the team that wins will be the team that is better at American Football.

The hidden ace of the Deimon Devil bats appears, being the crucial key to their new formation: Wishbone.

The Devil Bats have made a comeback, the score is 14-12, and Deimon has the ball. Kakei finds a way to exploit the weakness of the wishbone formation. However, Hiruma finds another way to overcome their new plan, and they score another touchdown, putting the Devil Bats in the lead.

The game continues with a stalemate with both teams trying to break the trend and score, knowing that this will lean the game highly in their favor.

The Poseidons reveal a new formation called High Wave. Hiruma immediately spots its weakness, but Sena cannot get past Kakei. The ball is turned over to Kyoshin, and they score a touchdown, giving them a five-point lead. They try to get an extra two points, but due to Hiruma's plan, the ball is intercepted by Monta. With 1 minute left in the game, Deimon's only hope is for Sena to get past Kakei.

Sena breaks through Kakei's Moby Dick Anchor, but he is stopped just inches from the touchdown by a desperate Mizumachi. Hiruma uses their last timeout with two seconds remaining and the Devil Bats behind by five points. They decide to have Sena jump over their line in a joint combination with Monta so that he goes twice as high. The plan succeeds, and they score a touchdown, winning the game. Kakei tells Sena that it no longer matters whether he is the original Eyeshield 21 or not, but that what matters is that he is one of the most excellent players Kakei has ever seen, and that Sena is Eyeshield 21.

Riku appears and talks about his past and how Sena could run because of him. Riku asks Sena who he thinks is the best player. His answer? Shin. He then asks why and Sena says because "his power and speed are incredible." Riku is part of Seibu who missed the game before due to his pride.

The whole Deimon team goes to a sports meeting where the team is divided into two teams, Mamori san, Hiruma, and Yukimitsu (the smart team) vs everyone else on the football team (the brawn team). They play tug-o-war and other sports. The "brawn team" finally finds out that Hiruma has plotted all the sports games to teach the team how to do the "bump" in his evil plotting ways by handcuffing everyone's hands (a trick first used by the Taiyo Sphinxes team).

Ishimaru misses practice because another member of his athletic club injures his knee at a practice and he can't run for three weeks. Sena offers to send Eyeshield 21 to run in his place but figuring Hiruma won't let him, goes as himself. Sena helps the athletic club reach the finals, where they win first place.

Riku learns that Sena's speed has increased, and also that he is secretly Eyeshield 21. Hiruma confronts Kid and tells him that between Riku and Eyeshield 21, Eyeshield is the fastest running back. He asks who Kid thinks is the strongest quarterback in Kanto. His answer: Yoichi Hiruma.

The game against the Wild Gunmen begins. Doburoku tells the Devil Bats that if they lose concentration for even a second, they will surely lose. Deimon kicks off the ball first and it is received by Riku. He shows the power of his technique, the Rodeo Drive, by running straight to a touchdown. However, when Seibuu kicks off to Deimon, Sena returns the favor by doing the same, running a straight touchdown, being stopped by Riku just a second too late.

Unable to stop Kid's Quick and Fire technique, the Devil Bats decide to reveal the fruit of their bump training. Seibuu counters by bringing in the Iron Horse, Tetsuma. Monta is unable to stop him, and he scores a touchdown, with the extra point successful, making the score 14-6. Hiruma tries to trick Kid into a quick pass by using a Zone Blitz, but he fails and Kid rushes to a touchdown.

The Devil Bats are in desperate need of a kicker, and Musashi is watching the game from his father's hospital room. Without a score before halftime, the Devil Bats have a slim chance of victory, so Hiruma decides to kick the field goal himself. The kick is close, but it hits the side pole and is no good. Using a strategy that relies on nothing more than Kurita's brute force, the Devil Bats get a touchdown, lessening the point gap.

Trying to prove to Sena that he is the better player, Riku fumbles the ball. Sena intercepts it and runs straight to a touchdown. With Deimon only down by 2, Seibuu gives the ball to Riku. Sena tries to stop him, but Riku gets by him easily, scoring another touchdown for Seibuu.

There are 9 minutes left in the game, and Deimon is behind by 9. They try to make up the difference, but Sena cannot get past Riku. With only 1 minute left, Sena finally gets past Riku's Rodeo Drive and scores a touchdown. Deimon is only behind by 3 points.

Kid tells Hiruma that he fell directly into his trap, and that everything is always too good to be true. Hiruma reminds Kid that he told him that Eyeshield would definitely win, and Kid tells Hiruma not to forget that he said Hiruma Youichi is the best quarterback in the league. They part ways, saying that the rest of the battle will be a battle of wits, and Hiruma decides to do an onside kick.

After losing to the Seibu Gunmen, Tetsuma saves Monta from getting Deimon suspended from playing. Hiruma reveals there is a seat left in the Tokyo Tournament so they still have a chance to be in the Christmas Bowl. Deimon attends a summer festival. Mamori invites Riku. Riku tells Sena to promise to remove his eyeshield mask before the Kantou Tournament.

The Bando Spiders play against the Oujou White Knights. The Spiders are in the lead due to Kotarou's kick. Deimon is stunned that a small Bando player can take down Otawara and the team seems to know Oujou's passing routes. However, in the end, Oujou wins 14 to 3 and are set to play the Wild Gunmen.

Deimon realizes that they will need a kicker to win their game against the Bando Spiders. Sena and Monta try and convince Musashi to rejoin their team; he reveals that he quit the team to take care of his father and their construction company. In the end, he promises to rejoin once his father recovers.

Sena and Suzuna go to retrieve their helmets and cleats at a store where Sena sees a helmet with an eyeshield on it. Akaba is revealed to be the owner of the helmet. Akaba proclaims he will defeat Eyeshield 21 and take the title that be believes rightfully belongs to him.

Mamori tries to help Sena, and Sena can't find enough time to change into Eyeshield 21! So after school, he practices by himself by the riverside. After catching a cold because of training in the rain, Sena is forced to stay home during the Ojou vs. Gunmen game. Deciding to go, he manages to get there about halfway through the game, when Riku and Shin are in a showdown, but problems start when Mamori spots him and urges him to go home. Then, shy Sena says the words that Mamori was sure she would never hear: "Leave me alone! I want to be here right now!"

Before the match, Sena removes his helmet to reveal his identity to the world. Mamori accepts who Sena is. The game against the Bando Spiders begins.

Using a trick kick in the beginning of the game, Akaba recovers the ball and Kotarou scores a field goal. Things start to look bad for Deimon as they are apparently caught in a loop from the Spider's web, giving Bando a significant lead. Meanwhile, Musashi watches the game from his father's hospital room.

The game continues to turn in the Spiders' favor, as they score yet another field goal, giving them a 20-point lead.

Using a combination run with Hiruma, Sena is finally able to score a touchdown. Meanwhile, at the hospital, Musashi is told by his father to return to the Devil Bats. Encouraged also by his co-workers, Musashi rushes to the field to rejoin the team.

Musashi arrives just in time and scores a 45-yard field goal, and Deimon is now only behind by eleven points. Towards the end of the episode, a strong wind arises, confusing the players.

With the wind's speed increasing, passing is impossible, and Deimon is left with no other choice but to have Sena run the ball. Making use of Monta's catching abilities, and Hiruma's Devil Bat Laser Bullet, Deimon scores a touchdown.

Taki begins to cause problems for the Devil Bats in the critical fourth quarter of their game against the Spiders. Behind by 13 points, Deimon struggles desperately to close the point gap.

With four minutes left in the game, the score is 36-30, Bando to Deimon. Sena manages to get a touchdown with the continuous use of the Devil Bat Ghost. At 36-36, Deimon scores the last point with a kick.

Deimon has beaten the Spiders and are going to the Kantou Tournament, where the high-school champs of Kantou face each other to choose who will go to the Christmas Bowl. At the award ceremony, the All-Stars are announced.

A "halftime show" of short player-centric stories, interspersed with chibi shorts.

The Cream Puff Tournament is a tournament in America where 4 teams representing different continents face each other. Representing Europe and Russia are the Northern Light Blizzards, Asia is represented by the Deimon Devil Bats, America is represented by the NASA Shuttles, and Africa is represented by the Savanna Survivors. The Blizzards play against the Shuttles and win.

Panther and a couple of the Devil Bats play a street game against a rival neighborhood to help Panther regain his love of football.

Sena takes up wrestling in order to try to defeat Ivan's mammoth tackle.

The Huh-Huh brothers take on a bull in order to train for the Creme Puff Cup.

Devil Bats vs. Savanna Survivors. In the end, the Devil Bats easily win. After seeing the Devil Bats practice, Panther, Homer, and the others decide to get Coach Apollo back.

Devil Bats vs Blizzards. Trailing 17-0 after the first half, the Blizzards send in their secret weapon to injure Sena. Meanwhile, the NASA Shuttles try to convince Coach Apollo to return to the team.

0:17 Blizzard to Deimon. Ivan's twin brother Wan has been placed on the field with current goals. They perform Snowstorm Tackle and knock Sena unconscious. The Blizzard gains 21 points and have the lead now. Deimon begins to lose faith in each other until Hiruma tells them they must do their best. They manage to stop the other team from scoring any more goals and Sena regains consciousness. Sena manages to beat the Snowstorm Tackle this time and gets a touchdown, winning the game 21:24.

Recap of the Fall Tournament

The challenge to the Death Game has started. The first team to play against are the Harabishi Deers. Kurita must face up to defeat his long time hero Onihei.

Game 2 of the Death Game. Zokugaku vs Deimon. Using only 1st year students, Deimon tries to beat the Chameleons.

Deimon has a school festival, where a large contest is being held. Everyone decides not to participate, since Hiruma will probably win, but now, it turns out Hiruma isn't playing! The team divides into groups of three (Sena, Suzuna, and Omosadake; Monta, Mamori, and Kurita; Kuroki, and two cheerleaders; Ishimaru, Yukimitsu, and Komusubi; Togano, Musashi, and Taki; Jumonji and the team mascots). Each tries to outdo the others, but at the same time, for the very first time, Sena's enjoying the festival, where he's not treated like a gofer anymore.

Sena starts to have nightmares about football. Hiruma gives the team a break to rest up. Riku invites Sena to watch the Ouju White Knights train. Shin and Sakuraba are training in the forest and Sena and Riku go after them. Everyone in the team goes to practice, leaving Sena in the woods. Sena gets lost and is saved from a bear by Shin. Shin tells Sena he is experiencing pressure from feeling he must win the game and that he should relieve it by practicing to gain confidence in his skills. Sena is able to relax now.

The regional champions go to a place where they decide which regional teams will play against who for the Christmas Bowl. Deimon is placed against Shinryuji. Poseidon challenges Shinryuji and Shinryuji wins. Agon comes after the match is over and calls the Poseidon team rubbish. Mizumachi tries to hit Agon but gets his shoulder dislocated by him.

Sena, Monta, and Suzana visit Mizumachi in the hospital. When Mizumachi overhears how he could not beat Agon, he goes missing. Sena finds him crying and they talk. Mizu says he's afraid of Agon and Sena says he is too but he loves American football so he will continue to play it. Mizu realizes he's become afraid of football and decides to play a game with Sena to overcome it.

Kyoshin and Bando team up to beat Deimon in the 3rd death game.

In the fourth death game against the Taiyou Spinx, Deimon is left short-handed after Jumonji gets arrested for beating up some punks who were harassing a young girl. The Sphinx declare that they too will forego going to the Kanto Tournament if they lose to Deimon; however, the game ends in a 7-7 tie after Jumonji makes a last-minute comeback, completing Deimon's line and opening up a hole for Sena to score a touchdown.

Deimon vs. the NASA Aliens. They use their death climb training in the game, ending with a score of 77-84!

An interview with Hiruma and Agon. Later, Sena protects Mamori from Agon.

A recap of the Shinryuuji and Hiruma, Kurita,and Musahi's involvement.

The Devil Bats are given a night cruise on a ship to relax before the game. When dinner time comes, it turns out someone has eaten their dinner. Sena is put in charge of finding out who did it. Then a blackout occurs; when power is restored, Mamori's briefcase is missing and Monta has been kidnapped. Sena sees someone running and chases after that person. It turns out that was Shin and the Ojo White knights are also on the boat. The food was eaten by Otawara, Shin caused the blackout, the briefcase was never missing, and Monta was mistaken for a circus monkey and placed in a cage.

Monta battles Ikkyu in a catching battle. Monta loses but vows to beat Ikkyu next time with 100% effort.

Unsei explains to Sena and the others why he trains so hard. It is to keep Agon, his younger brother, from risking his career of being a football player by causing trouble with assaults and fights. His goal in life is for Agon to be the #1 football player.

Finally, the match with Shinryuji draws near. Doburoku tells Yukimistu that he will participate in this game, much to the team's delight. At Shinryuji, their coach shows them information that they have on the Devil Bats on a waterfall and projection screen, when Agon arrives (with two girls in tow) and says he'll crush them all, Hiruma especially. Sena's face appears on the screen, and Agon suddenly throws one of the underclassmen into the waterfall, adding "And that piece of trash too." At that moment, Sena shudders because he suddenly has a bad feeling. Later that night, Suzuna texts Sena, asking him if he is afraid. Sena (thoroughly peeved) texts back that he's not scared, he just can't believe that this is all happening. Suzuna asks him if this is his goal, to which Sena replies "No, I want to go to the Christmas Bowl, so we'll win, I promise!" With that said, Suzuna smiles in her sleep, saying that she'll be behind him, every step of the way.

The game begins. Shinryuji gets the lead on Deimon. Agon proves to be unstoppable, even for Hiruma. Agon and Unui show their best technique because of Hiruma's provocation. The Dragonfly is a move where Agon or Unsui is the quarterback and they pass to each other with an overhead throw. This confuses the opponent as to who has the ball.

The first half ends with 32:0, Shinryuji in the lead. The second half begins after Hiruma tells the team to give up and try and not get injured. The team understands he means they should get rough, meaning that Musashi will kick the ball to the outfield. They catch the ball and Yukimatsu joins in for the next play. Yukimitsu knows where Hiruma will throw the ball; this move is called Option route, where Hiruma chooses the best place to throw the ball. Yukimitsu catches it and gets Deimon their first touchdown.

Hiruma tells Sena that he has to blitz Agon on every play, but it just doesn't seem to work. Once, while Agon is about to pass the ball, he says that they are getting a "game over," which makes Sena suddenly furious, to the point where he forgets he is in a game and jumps to attack Agon, who dodges, but is slightly disturbed. After a while, Shinryuji goes with a run, which in reality is a trap. Sanzo back passes to Agon just as Sena rushes up. Because of Sena's intense concentration on Agon, Sena somehow sees the football, even though it is in his blind spot, and knocks it away with a superhuman jump to the side. Everybody goes for the ball, and Juumonji manages to get it, thanks to Kurita. As he runs with the ball, Agon catches up and stops him. Juumonji, realizing what Sena had to go through, takes one more step and crosses the goal line. It seems that everything will be all right, but then Sena's legs start to have problems, and Doburoku cools them down with an ice pack. In the meantime, Unsui notices that Agon has acknowledged Sena as a rival, and thinks that it's great. An intense rivalry aura develops between Agon and Sena, and Shin once again notes that Sena will be improving to no limits.

At the beginning of the episode Shin comments that even though each individual in Deimon is lacking, as a team they are already regarded as the strongest in Kanto, hinting the result of the game. This episode centers around Monta's individual battle with Ikkyu. Monta wins Ikyuu in an aerial battle by snatching the ball away from him in mid-air, and scores a touchdown by successfully catching a long pass. Ikkyu finally admits Monta as a rival but still states that the 'Number One' in Kanto is still himself. Monta's successful touchdown brought back a momentum to the Devil Bats. Near the end of the episode Agon shows his true strength by imitating Sena's Devil Bat Ghost and passing Sena with it, proving the reign of natural physical talent such as himself as compared to the Sena who had completed the move by intensive training. Sena's knee starts hurting after he used Devil Bat Ghost too many times and caused an 'act' incident between Hiruma and Musashi about the future of a sports player. In the next play, Eyeshield 21 intercepts Unsui's 'Tranquil Reflections' by abandoning the post of defending the prodigy, Agon.

Sena grabs the ball and is about to score a touchdown when Agon gets in the way. Agon is about to strike down Sena, but when Agon suddenly insults the Devil Bats' dreams of going to the Christmas Bowl, Sena's newfound fury gets the best of him, and he tries to attack Agon. Agon chops Sena's arm away, and then tries to stop Sena, who uses the Devil Bat Ghost to get away. Agon chases after Sena, who suddenly realizes that the God Speed Impulse won't work on something Agon can't see, so he pushes down on Agon's helmet in his blind spot. Sena actually slams Agon's head into the ground and scores a touchdown, making the score 35:28.

58 seconds remain with the score at 35:28, Shinryuuji leading the Deimon Bats. Deimon must score a touchdown in those 58 seconds to win. After gaining a short amount of yards and spiking to stop the clock, Hiruma pulls a long pass to Monta. Monta catches it and with 4 seconds to go, is tacked by Agon 20 yards from the goal. The timer becomes zero and Deimon loses.

It turns out that before Monta was tackled down, he reached his hand out and grabbed the grass on the "out of bounds area," stopping the clock and regaining those 4 seconds. Within those 4 seconds, Hiruma distracts the other team by causing an uproar in the audience. When it looks like Hiruma is getting the crowd worked up this sets him in motion and the ball is directly snapped to Sena. He runs it but gets covered by Agon. Sena then tosses the ball in the air and Hiruma catches it and scores by running it past Agon. The score is now 35 to 34. Touchdowns are worth 2 points now and kicks are worth one. With no chance to win in a tiebreaker, they must score a touchdown on the last play. Hiruma takes the ball and runs towards the Shinryuuji defense line. He throws the ball in the air and Sena catches it and scores a touchdown, which wins the game 35 to 36.

After winning the game, the players line up to shake hands. Agon refuses to believe he lost and is about to attack Hiruma but Unsei punches Agon and takes the blame for their team's loss. Agon calms down and says they will beat Deimon next spring. Deimon celebrate their victory with a party while Hiruma sleeps with the video of their previous game on.

The Hakushu Dinosaurs are going to play the Taiyou Sphinx. Deimon comes to the stadium to watch the match. At the entrance Maruko introduces their star player, Gaou, to the Sphinx and says the Sphinx will lose. In the match the Sphinx take the lead in the game 0:21... until Gaou joins from the benches, when it ends at 28:21 with every player on the Sphinx team injured and they are forced to forfeit.

Seibu Wild Gunmen vs. Misaki Wolves! Before the game, the Wolves' long-legged Kamiya Taiga taunts Riku by challenging Sena as his rival. It turns out he's not all talk, and as a result, Riku loses his cool. Could this mean elimination for Seibu?

Riku loses his cool and gets angry at the Wolves. This puts the whole team into frustration. Reassured by his teammates (including a very sick Tetsuma with a cold), Riku regains his calm and returns to the field with the debut of his perfected technique: Rodeo Drive Stampede! The game ends with 21:48, victory for the Gunmen.

As a celebration of their progress, Mamori decides to buy Sena and Riku new shoes. On his way to meet them, Riku runs into Shin, who demands to be taught the running technique behind Rodeo Drive.

Oujo White Knights vs. Sado Strong Golems! The rock-hard bodies of the Golems seem to present Oujo with a problem, but Shin reveals the "completed" version of Spear Tackle, the Trident Tackle. Oujo wins 42:0. In the end Hiruma's father calls him and says he waited for Hiruma at their meeting place but he did not come. His father says he is sorry he cannot see Hiruma at the Christmas Bowl as he has to leave Japan. Before he finishes talking, Hiruma hangs up and throws his cellphone away with his face hidden from the camera.

Hiruma and the rest of the team go to spy on Ojo at their high school festival to find out about the ballista, but all of the other teammates except Hiruma, Kurita, and Musashi get caught up in the festival, namely a quiz show.

A kid in a wheelchair who idolizes Sakuraba realizes he's not the ace of Ojo. He sulks at a river until Sena and the others cheer him up. He returns and talks to Sakuraba, who says he won't be the ace until he is better than Shin and that's why he trains so much. The kid offers him a wristband that he asks Sakuraba to wear in the game against Deimon.

Three days before the game between Deimon and Ojo, Hiruma takes the team on a helicopter to make them remember the lines where the defense of Ojo Knights are weakest. The coach makes the team wear masks that greatly reduce their oxygen intake, which will greatly increase their lung intake for one day. The coaches of Deimon and Ojo meet on the field where the game will take place and pour wine onto the grass so the heavens may help the losers of the match "recover" quicker.

The two teams' catchers and running backs are interviewed the day before the match. Ojo's coach increases the difficulty of their training and 20 spare teams of Ojo quit due to it. Hiruma trains his pass and has a 96% accuracy. Sena trains with Hiruma and learns that his runs are too simple and that there is a fraction of a second where he stops when he does the Devil Bat Ghost.

The day has come for the Ojo White Knights and Deimon Devil Bats to face each other. It is raining hard and the Deimon will start the attack. Finally Ikari will play in the game as his debut game; he is so pumped that he breaks a chain with brute strength. Sakuraba is utterly serious about taking the title of ace from Shin.

The battle between Ojo and Deimon has started, and Deimon gets to attack first. Hiruma made a strategy to help Sena catch the ball from the kick off. Sena catches the ball then runs straight for a touchdown, but Ojo's line blocks his way. Deimon's line defends Sena but fails. On the second try Sena succeeds in going through but Otawara blocks his way. On the third try, Deimon creates a strategy to defeat Ojo's line and Sena uses his Ghost against Otawara. Then he comes up against Shin but fails to pass using Devil Bat Ghost and gets hit by the Rodeo Drive + Spear tackle or the Trident Tackle.

Ikari makes his debut play. He uses Prison Chain on Sena and blows him off the field, but he continues to attack Sena even when the referee blows his whistle. Jumonji defends Sena and gains a bruise on the arm. Ikari is assigned to come against Jumonji but he becomes scared every time it happens. It appears he had an experience with Ikari in middle school. He is encouraged by his father, which helps him defeat Ikari and Deimon makes their first down.

Monta catches all the passes of Hiruma. The Ojo Knights are in a tight spot. Sakuraba asks if he can play, but he is denied because he is supposed to be the key in the second half. Hiruma decides to use the Shotgun Formation of the Gunmen against Ojo. After a play with Monta against a tall Ojo player (where Monta succeeds), Sakuraba with the help of Shin finally gets his coach's permission to join the defense. He starts to intercept and block Monta's catches.

The Bats are on their fourth down and 40 yards away from the goal. Musashi kicks the ball. It hits the goal and goes in. Now Ojo is on the offensive. Four Eyes (Takami) says that they will break through in front. Using Ballista, Shin runs in the opposite direction then breaks through the line (this include Kurita). Ojo gains their 1st down.

Takami once again tells Deimon which direction he will running The Ballista. Hiruma suspects that this is not the usual Takami but cannot seem to figure it out. The play beings and as said Shin runs to right. All defenders run to cover him but Takami then runs to the left for a QB SNEAK! As Deimons defenders run to intercept him he then passes an Everest Pass so high that the whole stadium thought Sakuraba would not be able to catch. As Monta tries to catch up Sakuraba stands by the end zone waiting for the ball but then Hiruma shows up and blocks Sakuraba! As Monta catches up the ball thens suddenly turns towards the out-of-bounds area. Still, Sakuraba jumps for the ball and catches it and tips a toe in the endzone for a touchdown. They go for a kick but Kurita, (who's been secretly squatting for the whole season) jumps to block the kick! 6-3 Ojo 6, Deimon 3.

Shin stops the passing game of Deimon forcing them to use Sena. Sena tries to pass Shin with the Devilbat Ghost, but Shin simply turns around to stop him with the Trident Tackle. However Shin says there battle is not over, as Sena’s speed was not maxed out. Sena does another run and uses the Devil Light Hurricane (using opponents strength to push himself past), named by Hiruma, to pass by Shin on their third one-on-one. But Shin catches up right away and stops Sena, now also being equal in speed.

Having achieved the speed of light as well, Shin declares himself the winner off the battle between him and Sena. On Sena’s next run he loses the ball and Shin makes a touchdown making the score 13-3. After not being able to get a 1st down and with no way to stop Shin, Hiruma makes Mamori edit a video of Shin’s match and tells everyone not to let Ojo get another point till half time. While Sena spaces out the rest of the Devilbats manages to get the ball back and Musashi makes a field-goal just before halftime making it 13-6 for Ojo. Hiruma tells Sena not wuss-out as there is no one who is unbeatable.

Hiruma and Mamori go through the games footage to find a strategy. Meanwhile in Ojo’s locker-room, Shin says a 7-point gap is not enough as Eyeshield 21 is a player that improves with shocking speed during a game. As Suzuna motivates Sena, Hiruma finds a way to defeat Shin. He tells Sena to push Shin away using his arm strength. Right before the second half the sun comes out. After which Hiruma comments that if they get through the first 10 minutes the rhythm of the match will turn in their favor.

Sena uses a speed-boost to compete in power with Shin (playing leadblock,) who knocks him away with some effort, giving Hiruma the chance to tackle the runner. However, the speed-boost and many Devilbat Ghosts in the first half, end up being to big a burden on Sena’s legs and the give out on the next play. Hiruma tells him to keep playing but not run anymore, giving him chance to rest his legs. Everyone is now so focused on stopping Shin that it is obvious to Ichiro Takami, but Hiruma does not stop them from going after Shin. Takami uses the Everest Pass but it turns out that Monta was still focused at Sakuraba. Knowing he cannot make it if he looks back at the ball, Monta jumps up without looking.

The episode starts off with Oujou throwing a long pass. Monta intercepts it without turning around to watch the ball. Hiruma points out that Monta no longer needs to see where the ball's heading and dubs Monta's move Devil Backfire. Deimon's ball, Hiruma throws long overhead passes and Monta uses the Devil Backfire to catch it. After 5 minutes, the field dries and Sena is able to run at full speed again. Sena grabs on to Monta when he catches a ball and uses the Devil Hurricane for a touchdown.

Sakuraba attempts the Devil Backfire but failes and makes a nasty fall losing consciousness. He has backflashes and loses confidence. But as he wakes to Torakichi (wheelchair kid) and sees him struggle to stand up for the first time since his hospitalization, Sakuraba returns to the field with renewed spirit. He suggests to use a new comby play with Shin named Sagittarius (Sakuraba gets a short pass and Shin blocks the defense going to tackle him). After several Sagittarius’s a driven Sakuraba makes a touchdown, the score is now 20-13. The episode ends with Agon Kongo showing up in the tribunes.

Score is 20:13, Oujou to Deimon. Deimon's ball. When Shin tries to tackle Hiruma, Sena learns how to block the Trident Spear with a new move dubbed by Hiruma the Devil Stun Gun, which is a move to knock the opponent down or knock his arm away. Sena uses it and runs towards the end zone with Shin right behind him. They both run the same speed so it would be impossible to catch up to Sena. Shin jumps towards Sena and manages to get a finger in Sena's shoe, causing him to trip. Sena tries to make the ball touch the endzone but is knocked away by Sakuraba. The ball belongs to Oujou now.

Deimon makes a safety, making the score 20-15 and getting the ball back. Yukimitsu collapses having played longer than ever and Monta's endurance is also shown to have run out. Sena tells him he will pass Shin. To get past him, Sena uses the Devilbat Hurricane right away followed by the Devil Stun Gun. It turns out not to not be enough and Sena lets go of the ball. As Sakuraba tries to catch the ball, Monta comes after him and pushes him out of bounds, keeping possession on Deimon's side. Having used the last of his energy and is about to collapse, Monta is caught by his hero, Honjo-san (old baseball player). With his hero telling him not to give up until the end, Monta is once again fired up.

3 yards till the goal line and 1:21 minute left. Sena goes for a Devilbat Dive as Monta goes for a catch pose, leaving the choice to Hiruma. With the first two attempts Sena gets stopped 1 cm from the goalline by Shin. Deimon’s last down and with the same setup Sena tries to make a pass to Monta as he does a high dive, but Shin causes a bad pass. Sakuraba has the advantage with his position but Monta makes a one-handed catch! Score 20-22 and less than a minute left as Ojo is coming up the field fast. Ishimaru (trackteam) gets injured and Hiruma struggles who to replace him with, until he sees the look in the exhausted Yukimitsu’s eyes. With only 10 seconds left Shin goes on a bulldozing run. Two of the Ha-Ha brothers with the help of Yukimitsu finally take him down, but it is unclear if it is a touchdown or not.

Shin successfully made the final touchdown for White Knights, making the score 27-22 to the White Knights. When all is lost, it was revealed that Yukimitsu gained one last second for the Devil Bats by pushing Shin into the end zone.

The play comes down to Sena against Shin one on one. Shin's power and speed stopped Sena many times before. With time running short, Sena has the ball and runs to the endzone and Shin charges him head-on. Sena manages to get through Shin but he catches up and manages to knock Sena down with two fingers. Sena manages to get one hand on the ground to bounce back up. With the Devil Bat Dive running at 4.2 seconds, Sena uses Shin's Trident Tackle to go 4.1 seconds and gets the touchdown that wins the game. The next match will be Deimon against the Dinosaurs and the winner will go to the Christmas Bowl. eight to nine years later, Sena is on a team with colors of grayish purple with a yellow lightning bolt. On getting the touchdown in the first few seconds Sena notices Hiruma on the opposite team. The series ends with Hiruma shouting "Everyone! Let's play American Football!"

The Devil Bats are resting at the Wild Gunmen ranch. The coach has agreed to train them. Hiruma mentions that Deimon does not allow extra-curricular activities after the third year so it's his and Kurita's last chance for the Christmas Bowl. That means they must improve in 40 days, not 405 (a year plus 40). Hiruma says the team must do the death march and that he will complete it even if it kills him. On the day the Devil Bats are supposed to return to Japan, the whole team chooses to go through the death march along with Hiruma and Kurita.