The escape starts from the Colosseum. Francesco Totti, Costantino Della Gherardesca, Fedez and Luis Sal, Diana Del Bufalo and Cristiano Caccamo, Claudio Santamaria and Francesca Barra are on the run for 14 days. They will all try to get away from the capital, but a team of "hunters" made up of former police officers, criminologists and white hat hackers, will do everything they can to find them.

The fugitives must change their hiding place continuously and should be very careful not to leave any traces behind. The HQ is ready to follow all possible leads. In particular, monitoring the phones of the fugitives' accomplices seems to be the key to a successful hunt, as both Fedez and Costantino risk discovering at their own expense.

Claudio and Francesca counterattack and try to spy who is on their trail. Francesco Totti tries to leave a false trail behind. Unfortunately for them, the HQ knows that trying to anticipate the fugitives' moves is better than chasing them. Especially when someone involuntarily helps the hunters. That holds true for Luis, who accidentally left his phone turned on.

The fugitives fine-tune their strategies. A former colleague helps Francesco Totti distract the hunters, while Fedez and Luis try to confuse the investigators with false clues. Diana and Cristiano split up, heading in two different directions. But the hunters know that even the best plans always have a weak point, that is, the accomplices.

The days go by and the tension is building up for those who are still on the run and the HQ has proven to have learned from their mistakes. Due to stress, misunderstandings occur between Claudio and Francesca. Francesco Totti, on the other hand, is forced by the hunters into an unexpected training session.

With just 48 hours to go, the fugitives are informed about the place they have to reach in order to be safe for good. Fedez and Luis are still facing some urgent issues: they are literally surrounded by the hunters.