A couple in Louisville, Kentucky who both suffer from hoarding risk losing their children if they don't comply with numerous citations given to them by the city. A woman's food hoarding in Milwaukee, Wisconsin is so bad that she places herself at risk for food poisoning.

An Everett, Washington woman's compulsive shopping has depleted her family's finances to the point where her marriage has become strained. She must clean out and sell the family home as part of the divorce settlement. An Olympia, Washington man is at risk of eviction from his government subsidized housing as his apartment is filled with garbage, human feces, bottles, and cans.

Adult Protective Services removed an elderly Marysville, Ohio woman's sick alcoholic husband from their home because of the hazardous conditions. The family's financial problems are complicated by their schizophrenic daughter, who is also a hoarder. A Torrance, CA woman who is an obsessive collector faces eviction if she fails to clean up her home.

A young man in Novato, CA, who also suffers from obsessive-compulsive disorder, hoards garbage (snack wrappers, empty bottles, and rotting food) in a two-bedroom townhouse he shares with his alcoholic father. A New Mexico elderly woman's animal hoard is so bad that every room of her home is cluttered with over 75 living and dead cats, cat feces, and urine soaked carpets and furniture.

A Seattle, Washington couple are facing imminent foreclosure on two houses as a result of a decision to buy a second home to solve the wife's lifelong hoarding problem. A Charlottesville, Virginia woman's relationship with her boyfriend is in danger as a result of her hoard, which has taken over their entire townhouse.

While the outside of Patty and David's home seems perfect, inside it is completely filled with unnecessary belongings. The hoarding is so severe that Patty's children have already been removed by child services. Bill's hoarding has haunted Lorelei for 25 years. Lorelei has even hurt herself tripping over Bill's piles of belongings. She threatens to leave him if he can't make the house livable

A man in Mobile, Alabama has failed to meet three court-ordered deadlines to clean his yard which is filled with junk cars, scrap metal, and old appliances. A single mother in Atlanta, Georgia is concerned about her hoarding behavior when her seven-year-old son begun to exhibit hoarding tendencies. Her son has cried hysterically over things like a rusty chain and an old used cotton ball when she attempts to throw them out.