After winning another BAFTA for their hit comedy series, "Lyman's Boys", writers Sean and Beverly Lincoln are approached by American television executive Merc Lapidus who tells them that he'd be thrilled if they'd accept his offer to write an American remake of the show. After some trepidation the couple decide to make the journey from London to Los Angeles. On their first day in pre-production, Sean and Beverly are told that Julian Bullard who stars in the successful British series will need to re-audition for the American adaptation. They also learn that Merc has lied to them and has never even seen an episode of their show and that the luxurious house they've been given is in fact, just an unused set. Bullard is not given the job and the Lincolns are told that Matt LeBlanc will get the role instead.

Sean and Beverly are still reeling from the network's decision to cast Matt LeBlanc as the star of their show. However, when they meet him at a swanky LA dinner party at Merc's house, Matt couldn't be more charming or flattering about their show. Unfortunately, over time the natural animosity between Matt and Beverly rises to the surface, and Beverly learns just how much you don't want the former friend as an enemy.

Beverly can't stand Matt, and the feeling is mutual. As it's all she can do not to throttle the star of her show, she tells her husband, "He's yours." Sean and Matt bond after spending the day together, including an extended adventure in Las Vegas, leaving Beverly feeling excluded. In a confrontation with Matt, Beverly learns just how 'big' a star Matt LeBlanc actually is.

Sean and Beverly have to retrieve Matt from a seedy bar outside LA so that the paparazzi waiting outside won't see him driving home drunk. What follows is an all-night road trip which takes the trio from a run-in with a paparazzo to Matt's ex-wife's house and finally to his son's bedroom, where Matt is forced to confront the mess he's made of his life. The transformative evening even manages to bring Matt and Beverly closer together.

Sean's infatuation with the lovely "Pucks!" actress Morning Randolph is given an opportunity to blossom when Matt invites the two of them to a charity benefit. Sean realises that his attraction to her may be mutual. Meanwhile, Beverly and Carol share a joint and commiserate about the men in their lives. At the end of the night, Sean has a difficult choice to make, and Beverly learns that she has more to worry about in regard to her husband and the actress than even she realised.

Convinced that Sean is having an affair with Morning, Beverly packs a bag and leaves, intending to head back to London. However, in her distress, she is unaware that she's driving on the left side of the road. Beverly doesn't realize her mistake until she has a head-on collision - a collision which leads her down a road with even more dire consequences.

A final goodbye between Matt and Sean takes an unexpected turn involving a missing Jaguar, a red-nosed reindeer, and the smell of cinnamon.