11 year old Chyna starts her first day at High School as part of the Advanced Natural Talents (ANT) Program. There she meets Olive (who is smart) and Fletcher (who is a good artist and has a crush on Chyna). Chyna's two new friends help her learn the ropes of her new school. But, Chyna of course doesn't fit in. So, she decides to sneak into a party and show the High Schoolers what shes got. But, Olive, Fletcher and Cameron (Chyna's brother) might ruin her chances.

Chyna decides to get involed in some clubs and sports and joins Cheerleading. Inspired by their friend Olive and Fletcher start a lunch club.

The A.N.T.s get their own lockers and Olive's is next to Cameron's. But, Olive annoys Cameron. Meanwhile, Fletcher goes to great lengths to impress Chyna.

Chyna wants to stay up to watch High Heels High and Darryl gives her special permission if she studies after a couple of episodes; however, she stays up all night, and when she aces her science exam, she thinks that the teachers are giving her and the ANTs special treatment so they can compete and win trophies for Webster High. Meanwhile, Lexi and Cameron find Principal Skidmore's phone and keep it in order to receive the reward.

After Darryl gets Chyna a bag from the evidence locker at the police station and finds a new designer bag inside it, he accuses her of shoplifting and sends a police officer undercover. When Chyna, Fletcher, and Olive find out that "Charlie Brown" is a cop and that he is spying on them, they pretend that they are robbing a house.

After being denied an entrance to a school dance, Olive tricks Chyna into running for student council, Angus then tells her that to run for A.N.T. rep you need to participate in every school activity and Olive was the runner up. So Chyna tricks Olive into running too. Meanwhile, Fletcher feels ignored from China so then Angus then tells him in order to get a girl to like you you first need to relate with their dad. Fletcher then befriends Chyna's dad to see if he has a possibility with China but Cameron gets jealous. At the end, Cameron beats Chyna and Olive for student council and Chyna's dad starts hanging out with Cameron again

Fletcher tries to impress Chyna, but she is too concerned about Gibson after he tells her that he has been feeling lonely. Chyna and Fletcher find out that Sofie, Gibson's ex-girlfriend from his childhood, is in jail for a robbery. So they take Gibson to the jail to show him that Sofie is a criminal, so he can get over her and hopefully stop spending all his time with Chyna and Fletcher. Meanwhile, Lexi tries to get on the front page of the news, but must show Olive that she's done something newsworthy.

Chyna falls for a new student in the A.N.T. Program from England. He's another artistic genius who goes to school as a robot. But when Chyna tries to ask him out, he asks for advice from Fletcher. Chyna tells Fletcher there's a artistic guy that she is secretly in love with, and if she should ask him out. and Fletcher thinks she is thinking about him. But when he finds out that Chyna and the new kid from England are going out, Fletcher gets help from Angus to sabotage the date. Meanwhile, Darryl challenges Olive and Cameron at the arcade to see who can get the highest score on a game, Donkey King.

Cameron accidentally uploads a video of Chyna singing. To her luck, Hippo, a music producer, sees it and wants to make a music video, but Chyna refuses after he tries to change her image. Meanwhile, Fletcher, Paisley, Olive, and Angus compete in home-economics.Hippo says films are in and music is out , he end up doing Cameron's movie instead of Chyna song.

Principal Skidmore gives out Wacky Awards and everyone receives one except for Cameron, so Chyna and Olive try to help him find his talent. They make him believe that he is a psychic by making everything he predicts happen. Meanwhile, Fletcher finds out that the dinosaur nuggets at the cafeteria have been replaced; he goes to the board meeting to get them back.In the end Cameron finally knows his not psychic after he predicts the end of the world and it does not happen.

When the school cannot afford to pay Gibson's salary, he gets fired, so Chyna, Olive, and Fletcher try to raise money by doing a web-a-thon called, "Save Gibson". Meanwhile, Cameron pretends to be an elderly man because Lexi needs to show a former pageant queen that she volunteers at a senior center in order to keep her pageant crown.

Chyna and Fletcher meet Zanko, Fletcher's all-time favorite artist. Zanko is having trouble with inspiration, so Chyna urges Fletcher to give Zanko one of his paintings to inspire him, but when Zanko passes the painting off as his own at his comeback party, Chyna creates an elite team to rescue the painting and gets the help of Olive, Angus, and Wacky. Meanwhile, Paisley and Lexi audition to be a princess for a kid's birthday party for Roxanne.

Olive becomes the new history teacher after the previous one quits due to Chyna unintentionally upsetting him. Olive decides to be a fun teacher, but her kind of educational fun that involves reenactments of historical events ends up with her being spit-balled by the other students. So Chyna tells her to demand respect, but she overdoes it by becoming mean and giving both Chyna and Lexi detention, forcing the rivals to team up to get rid of her. Meanwhile, Cameron accompanies Darryl in a police ride-along for a school report.

It’s Halloween at Webster High School and it’s Chyna Parks’ first day in the Mutant Program, where monsters go to school with normal high school students. Chyna is Medusa so she fits right in with her new Mutant Program friends: Olive, a mad scientist, Fletcher, a vampire and Angus, a zombie. However, Lexi and the normal kids are terrified of the mutants, so Gibson pairs everybody off to help prepare for the Halloween dance.

Chyna is overheard singing by pop superstar Madam Goo Goo, and is totally star-struck when she is given Goo Goo’s phone number so they can work together on a song. However, when the ANTs go on a field trip to a fortune cookie factory, Chyna realizes she lost Goo Goo’s number. So Olive, Fletcher and Angus help retrace Chyna’s steps back to the factory to find the misplaced number. Meanwhile, Lexi finds out she wasn’t invited to a fellow cheerleaders birthday party.

When a deafening noise caused by Fletcher makes Olive lose her memory, Chyna, Fletcher, and Angus go to great lengths to get her memory back before Principal Skidmore dismisses her from the A.N.T. Program and sends her to kindergarten. Chyna later finds out that Olive actually regained her memory but is pretending that she has not. Meanwhile, Lexi and Cameron enter the Webster High dog show hosted by Gibson.

Chyna and Olive decide to host their own slumber party when Lexi does not invite them to hers. Chyna realizes that none of her guests have arrived except for Olive. Lexi video chats with her and to Chyna's dismay, all of her guests are at Lexi's slumber party. Chyna gets an idea since Olive painted her wall green, she will use it as a green screen. Chyna video chats Lexi and Lexi is jealous when she sees how much fun they are having, not knowing that it is a party scene from an old movie used as Chyna and Olive's background. Meanwhile, Fletcher agrees to help Cameron create a comic book character in order to get closer to Chyna.

A reality show called "America Needs Talent" arrives at Webster High, and everyone auditions to be on it; however, the only people who get picked to be finalists on the show are Chyna and Lexi. Unfortunately, Darryl is afraid of flying, so Chyna, Olive, Fletcher, Cameron, and Darryl end up driving to Los Angeles and end up in Solvang, California, where they get harassed by a walrus and get imprisoned in a windmill jail. Eventually they end up on the turbine of the windmill; Chyna rescues them by slipping through the bars covered in fish oil to slip through and flip the switch to stop it. While this is happening, Lexi's suitcase at the hotel in Hollywood is mistaken for a suitcase filled with money, so Lexi and Paisley try to find it. Later on, Chyna arrives just in time for the show, and both Chyna and Lexi make it to the final round. Lexi then pretends to be Chyna's friend to steal her song and humiliate her on the show, but Chyna overhears Lexi telling Paisley her plan and gives Lexi a fake song, costume design and props to use for the show. Lexi ends up as the one who gets humiliated, but after both performances, Chyna tells Lexi that there is enough spotlight for both of them. Meanwhile, Olive and Paisley enter a game show and Paisley keeps pressing the buzzer with goofy answers. Cameron, Fletcher, and Darryl wait in line at a popular food truck.

Principal Skidmore asks Chyna, Olive, and Fletcher to build toys for kids at an orphanage. They find out that it is a scam and instead Principal Skidmore sells it for profit. They then booby-trap the toys, but Principal Skidmore has a change of heart and gives the toys to the orphanage, so they must get the toys back. Meanwhile, Darryl follows Roxanne around to see what she is getting him for Christmas.

Fletcher asks Chyna out. Olive tells her to lie so she does not hurt Fletcher's feelings. Chyna says that she has a boyfriend so Fletcher lies and says he has a girlfriend. Olive suggests they should double date so the two must find fake dates. Meanwhile, Gibson coaches the cheerleading team because Coach Mandy died, but Lexi wants to win an upcoming cheerleading contest and thinks he is a bad coach. She fires him, and Gibson shows up at the contest with his own team.

When Chyna gets the lead in the school musical, Lexi tries to sabotage the show with the help of Fletcher, who does not want Chyna to fall for the leading man, Jared. Meanwhile, Cameron learns that Gibson has been living at the school and offers to let him stay in his family's living room.

Chyna, Olive, Fletcher, and Angus want to go to an upcoming concert with older kids, but they know Chyna's mom will never let them go. In order to convince her, they pretend they're going to see a kid's band, which backfires when she decides to tag along. Meanwhile, Cameron tries to get backstage at the concert.

Olive and Fletcher exclude Chyna from their product idea. Meanwhile, Paisley gets attention from her injuries and Lexi get jealous.

Violet , a sports prodigy with slight anger issues, joins the A.N.T. Program. Violet is not afraid of the older kids, including Lexi, who orders Chyna to keep the girl far away from her. Meanwhile, some of the older students take a drivers-education class.

Olive is shocked to discover that her pet robot, Hegel, is no longer functioning and has suspicious screwdriver scratches on his back. When a screwdriver is found in Chyna's locker, Chyna suspects that she has been framed and vows to find the real culprit. In the end, it is revealed that Chyna accidentally overfed Hegel. Various characters like Angus, Fletcher, etc. are revealed to be thinking they murdered Hegel by accident as well.