Living in a small village, Megumi's two main interests are classmate Natsuno Yuuki and a European-style house on a hill. One day, when her fascination with the house leads her to climb the hill, she vanishes.

As Toshio, the village doctor, seeks to uncover the exact cause of Megumi’s demise, reports of even more deaths in the area surface. Desperate for answers, Toshio and the Junior Monk set out to discover a pattern to these mysterious deaths.

Another villager displays the symptoms of the epidemic, but Toshio notices a new clue during a closer inspection. The family who just moved into the mansion on the hill make it around town, while their little girl shows a disturbing interest in Seishin.

As the death toll rises, Toshio and his staff gather to further examine the fatal sickness plaguing the isolated town. Seishin’s eerie admirer returns with an observation that makes her oddly wise for her age.

After visiting the surviving families of the deceased, Seishin discovers a peculiar similarity amongst every victim. Natsuno is tortured by helplessness as his visions of Megumi become terrifyingly close to reality.

No one in Sotoba—the village surrounded by death—is safe, as a frustrated Toshio fails to find a cure for the epidemic strangling his town. Convinced that Megumi has risen from the dead, Natsuno researches darker sources.

When Megumi’s friend suspects sinister activities are stirring at Kanemasa mansion—the last place Megumi visited before she died—Natsuno suggests digging up her grave for answers.

Natsuno and his accomplices open Megumi’s grave to test their theory. Meanwhile, the doctor’s recent remarks have Seishin pondering about the young girl from the Kanemasa mansion.

It’s clear to Toshio that the source of the deadly illness won’t be found using conventional methods. He and Seishin observe a patient overnight to catch any sudden changes in her condition—or possible moonlight visitors.

Toshio and Natsuno’s suspicions were true. Okiagari—creatures of legend that were once human that feed on the lives of others—are now stalking Natsuno.

While Sotoba’s villagers are debating the cause of the frequent deaths, the town shaman points her finger at the residents of Kanemasa mansion.

After Toru’s attack, Natsuno warns Kaori and her brother to escape the village before they fall victim to the vampires as well.

The population of the village grows thin as the blood-sucking okiagari claim more victims, including Toshio’s wife. With no strength left in his body, Natsuno invites Toru in for a last feeding.

Kaori’s father suddenly collapses. At the clinic, Toshio studies his wife’s corpse for clues on how to combat the vampires.

The Shiki are bent on keeping the outside world in the dark about the deaths in Sotoba. When Toshio threatens to expose them, a member of the Kanemasa mansion pays him a visit.

Sunako calls Toru to Kanemasa to share a piece of her past with him. The Shiki’s curse looms over Kaori as she finds her mother still in bed, pale and drained of energy.

As Shiki continue to rid the village of the living, Seishin finally makes a move. On another late night at the clinic, Toshio gets a visitor.

Natsuno’s return from death grants him a visit from Tatsumi. Hoping to enjoy his last days amongst the living, Toshio takes the mistress of Kanemasa to the village’s yearly festival.

The villagers band together to free their town from the grips of the Shiki. Meanwhile, Tatsumi decides what to do with Seishin.

Toshio leads those who haven’t joined the Shiki—or fled the village—on a raging, blood-soaked hunt, but there’s still one place they haven’t looked. As the vampires strike back, Seishin continues his watch over Sunako.

The villagers discover the Shiki’s last hideout, and the bloody war is nearing an end—but two Kirishiki's still remain. Will Seishin be able to save Sunako from the humans' vengeful wrath?

The last of the Shiki try to escape the village, but one of their own kind stands in Tatsumi’s way. What fate remains for the vampires and Sotoba—the village surrounded by death?