The first part, Everything, sees Professor Al-Khalili set out to discover what the universe might actually look like. The journey takes him from the distant past to the boundaries of the known universe. Along the way he charts the remarkable stories of the men and women who discovered the truth about the cosmos and investigates how our understanding of space has been shaped by both mathematics and astronomy.

The second part, Nothing, explores science at the very limits of human perception. Where we now understand the deepest mysteries of the universe lie. Jim sets out to answer one very simple question - what is nothing? His journey ends with perhaps the most profound insight about reality that humanity has ever made; Everything came from nothing. The quantum world of the super-small shaped the vast universe we inhabit today, and Jim can prove it.