Melissa of Sioux Falls, South Dakota has lived with a large lipoma on the right side of her neck for years, forcing her to wear sweatshirts to conceal it from everyone. Tyler of Litchfield, New Hampshire has cysts on his forehead, but his family's history of cancer has discouraged him from having them diagnosed. Tahj's body is covered in painful boils. Amber of Los Angeles has keloids on her ears that have given her years of discomfort.

Ronan of New York City has a lump above his left knee that has given him excruciating pain in his job as a flight attendant. Amber of Ada, Oklahoma suffers from hidradenitis suppurativa that leaves her clothes soaked in drainage. Sandy has a golf ball-sized lipoma on her neck that grew back after a previous surgery. Kristy of San Angelo, Texas has what is thought to be a milium on her left eyelid that gives her discomfort and affects her vision.

Mary of San Antonio, Texas has fatty tumors that makes her left leg disproportionate from her body and wants them removed before the day of her daughter's wedding. Physical trainer Anthony has a grape-sized cyst between his eyebrows that other doctors have refused to treat due to its proximity in the "triangle of death". Shane has a grapefruit-sized lipoma on his back. Brandi of Cincinnati, Ohio has an unusual lipoma above her left breast that has hindered her love life.

Diane of Lake Mary, Florida suffers from hereditary neurofibromatosis, which has prevented her from having children out of fear of passing the disease to them. Will of Hinesville, Georgia has a golf ball-sized lump on his right shoulder. Anthony of South Bend, Indiana has a tennis ball-sized lipoma in the back of his neck. Kai-Elle, a 47-year-old transsexual New Yorker, has lived with spider veins on her legs throughout her life.

Belinda of Pomona, California has a lipoma on her back that limits her neck and arm movement. Nicole of Portland, Oregon has a lump under her right arm caused by issues while breastfeeding her daughter 11 years ago, and she wants it removed before her wedding. Adela is a 62-year-old woman with over 400 seborrheic keratoses that developed after she gave birth to her daughter. Nick of Seattle, Washington has seven lipomas on his body and needs them removed professionally after he removed one on his own..

Taylor of St. Louis, Missouri has had a lump on her buttocks since birth that regenerated after a previous operation two years ago, and discovers that it is an extremely rare case of spinal dysraphism. John from Maui County, Hawaii has a breast-shaped lipoma on the right side of his waist. Noelle of Boise, Idaho wants her ear lobes restored after having stretched them to wear ear tunnels for years.