George Washington sends Daniel and Yadkin into ""Ken-Tuck-E,"" the ""dark and bloody"" hunting ground of four Indian nations, to find a site for a fort. Once they arrive, they encounter representatives of two of those four nations -- Shawnee warriors chasing a lone Cherokee warrior. Daniel helps drive the Shawnee away, and the grateful Cherokee, Mingo, returns the favor by showing Daniel and Yad an ideal location to build their fort. Yad returns east while Daniel remains with Mingo to explore the country.

An assclown named Flathead Joseph kidnaps the adopted daughter of a Cherokee chief and offers her to the Boonesborough settlers in exchange for a jug of rum. When it's revealed that the girl is in reality white, Daniel purchases her freedom. Then the Cherokee arrive on the scene and want to take the girl back to live with them. Some of the settlers do not agree that she should return but the girl herself wants to go

Yadkin is seriously wounded in a Native American ambush and insists that the Native American who wounded him was none other than Mingo.

Boone invites a widow (Bethel Leslie) and her hungry brood to town, but one of the children steals a telescope.

British soldiers and Indians surround Jemima as she tries to help Boone, wounded in the wilderness.

Boone chases a river pirate (Emile Genest) who plans to sell a load of stolen arms to Shawnees.

A British officer (Michael Rennie) captures Boone then impersonates him to win Indian allies; guest Frank DeKova

Israel becomes lost in the woods after fur thieves ambush him, Boone and Yadkin.

Yadkin's trickery leaves Boone the unexpected, and unwilling, owner of indentured Irish sisters (Fay Spain, Nina Shipman).

A bondsman (Peter Whitney) insists on returning a runaway slave (Brock Peters) unshackled by Boone.

A dream about a man whom Daniel thought was dead is followed by the appearance of three men at his door demanding that he take them to the site of a bloody Native American massacre.

Mingo plans to do more than protest a new treaty when he and Boone visit Virginia's governor general (Walter Pidgeon)

A band of Senecas kidnap Rebecca and ransack the Boone cabin. The unusual thing about this little group is that they are led by a white Tory officer.

Boone cannot believe a boyhood friend (Pat Hingle) murdered two Cherokee youths.

A Shawnee prophet (John Russell) predicts massacre for the settlers of Boonesborough; guest Patricia Huston.

Boone befriends a mother (Geraldine Brooks) and son (Kurt Russell), but learns the woman is accused of witchcraft.

While hunting, the Boones meet a delirious British officer (Macdonald Carey) pursued by vengeful Shawnees.

A condemned bounty hunter (Dan Duryea) who escaped from a military convoy takes the Boones hostage.

Boone assists a boy (Kurt Russell) and winds up at the mercy of a larcenous clan; guests Lloyd Nolan, Lane Bradford.

A Quaker family refuses to fight until Indians kidnap a daughter; guests Alexander Scourby, Jay Silverheels.

Boone commands four criminals recruited by Yadkin to haul frieght to Boonesborough; guests Sean McClory, Gordon Jump.

Timothy Patrick Bryan shows up in Boonesborough looking for his long lost daughter, Rebecca Boone. Rebecca wants nothing to do with the man because he abandoned her family when she was a child.

After returning from a trip to Virginia, Daniel and Mingo tell via flashback how they met the legendary Benjamin Franklin and almost got themselves shanghaied to England in the process.

An idealistic schoolteacher (George Gobel) incites Boonesborough's wrath by giving gunpowder to the Shawnees.

Boone seems guilty of betrayal when he allows Choctaws to capture the town's men

Lacking water and powder, the women and children of Boonesborough seem easy prey for attacking Choctaws.

Superstition runs rampant in Boonesborough when two mysterious travelers arrive and are followed by the appearance of a deadly panther.

Israel accidentally startles a passing peddler's horse and his goods are ruined. Daniel agrees to compensate Seth Jannings for his loss, but matters are complicated when Jannings steals a sacred mourning doll from the wife of a Native American chief and plans to hold it for ransom. Knowing that this could lead to major hostilities with the Native Americans, Daniel puts his own neck on the line to retrieve the doll from Jannings.

Jericho Jones gets the hots for a Creek princess and elopes with her. Needless to say, this event causes considerable disruption of settler-Native American relations.