Bandmates Jane, Scott and Vaughn stumble upon a mysterious amulet that enables them to see ghosts, all of whom want their help. First up, the trio grapples with the inescapable duties that come with their newfound power as a record company rep tries to sweet-talk Vaughn into going solo, exacerbating tensions between band members.

Once New York City's deceased community learns that the band possesses the amulet, a Big Apple visit to play a famous club is complicated by an inescapable mob of ghosts looking for the trio's help. Also, Scotty helps a dead man track down a potentially incendiary videotape, while the tortured soul who mugged Dennis years before seeks his forgiveness.

En route from Detroit to a gig in San Francisco, Scotty encounters a ghost who claims that the airplane they are on will crash---unless something is done to override faulty equipment. Meanwhile, in California, Jane and Vaughn dig up a deceased girl's body so she can be buried with her boyfriend.

After the Problem crashes an exclusive party for foreign dignitaries, the murdered Prince Torben of Mulravia calls upon Scotty and Jane to complete his diplomatic duties, which turn out to be less than noble. Vaughn's libido, meanwhile, leads him to get involved with a woman who may be an assassin.

The van gets stuck in a swamp on the outskirts of a Texas town, where the ghost of a teen, who claims to have been murdered, seeks Jane and Vaughn's help in telling his mother that he is dead. Meanwhile, Scotty's efforts to get a tow truck yield bizarre reactions from the locals.

While the band plays a club date, Jane is attracted to a cool disc jockey, but her attempts at a connection are continuously interrupted by an aggressive stalker ghost Meanwhile, Scotty and Vaughn deal with the ghosts of two subpoena servers who want revenge on the crazy recluse who killed them.

When Dennis' acute appendicitis is misdiagnosed, Scotty and Jane save his life by performing an emergency appendectomy with the help of a ghost doctor. Meanwhile, Vaughn is stuck with ghost duty when he finds that the hospital is jam-packed full of ghosts who need his help.

Lost on a Texas backroad, Vaughn, Jane and Scotty stumble onto a mystery when their van gets stuck in a swamp and they meet the lonely ghost of teenager. They decide to investigate when the apparition tells them he was murdered by the local Sheriff, but the truth turns out to be more evil than anyone had imagined.

While helping a ghost named Martin find his rancid corpse in his house, Jane and Scotty get arrested for murder. To get them out of jail, Martin and Vaughn have to find the real killer. Meanwhile, while in jail, Scotty must help a ghost, and himself, escape, and Jane must mend the relationship of a cop and his dead mother.

When Vaughn gets food poisoning and can't perform, he stays back to help the dead naked guy in their Laughlin, Nevada hotel room get back to the afterlife. Meanwhile, a gambling ghost helps Scotty win some cash, with some dangerous consequences, and Jane helps another gambler spend his winnings.

On a visit home, Jane is forced to protect her father and her awful stepmother Bunny from her jealous stepsister, Brandy who's now a ghost. Meanwhile, after Scotty spends all their money, he and Vaughn charge a fee to exorcise a ghost from a bar, they learn can only communicate through charades.

The Problem are shocked when they receive an invitation from the famous music producer, J.L. Crawford, to stay at his home and discuss recording possibilities. Of course things aren't what they seem because all Crawford wants from them is their ghost-talking power to exorcise a very annoying dead rocker from his home.

While performing in a music festival in Columbus, Ohio, the trio must elude a crazy professor and his assistant, who want the amulet and will kill to get it. As Vaughn's rival, Vance and his bandmates soon find out after a case of mistaken identity. Meanwhile, Scotty tries to keep his sanity while dealing with a nitpicky bellhop who's now a ghost.