The biggest dream of genius Ali Vefa with savant syndrome is to become a doctor. Despite his disability and all the prejudices he faced, he graduated from medical school, completed his internship, and all that remained was to specialize. He leaves the provincial city where he lives and sets out to start working as a Surgery Department Assistant at Istanbul Berhayat Hospital, where his spiritual father, Adil Erinç, is the Chief Physician.

Ferman tries to align Ali, who makes mistake after mistake on his first official working day; however, he himself is in the grip of a hidden problem. But Ali does not listen to Ferman and tension rises in the hospital. Nazli tries to help Ali in and out of the hospital. And Beliz and Adil are on the verge of parting ways.

Trying to adapt to his new life, Ali learns a bitter lesson and feels betrayed. A young couple's decision about their unborn child starts a legal battle at the hospital and splits the board. As time is rapidly shrinking, Ferman and Beliz come to the brink of an insurmountable abyss.

Ali and Nazli go to another hospital to get a donor organ for a liver transplant operation. However, the journey does not start as Nazli expected and it quickly turns into a disaster. At the hospital, Beliz tries to get Ferman into Tanju's surgery to secure an influential patient's surgery. All the upper echelon collides and Açelya's jealousy crisis finally explodes on Ali.

Ferman embarks on a mysterious journey. Taking advantage of his absence, Tanju decides to align the assistants and gives Ali his first case. The case carries a personal dimension for Ali. For the sake of this case, Ali is willing to get himself into trouble again. On the other hand, a rumor spreading to the hospital will raise Nazli's hopes.

Feeling that his chair is shaking, Tanju punishes the whole team and everyone stays on their emergency watch. When a chain-link car accident throws the emergency into chaos, each assistant is forced to take on their own case. Iron gets tighter as it gets cornered. Ferman, on the other hand, tries to prevent the rumors in the hospital. After all this running, Ali learns something new about himself.

Ali is trying to cope with and get to know his new feelings!

The trump card is shared in the hospital!

Ali finally finds the bike he was looking for. But Adil is not at all warm to the idea of ​​this bike. Things are complicated in the hospital anyway; When two complaints were made about him, the board of directors decided to meet with an urgent agenda and the subject is Ali's future in the hospital.

Ali is unhappy with being taken to pathology. Nazli does her best to return him to surgery. But Ferman stands firmly behind his decision, and Adil Hodja remains silent, aiming for something else. When a patient's family asks Ali for their surgery, an unexpected opportunity arises for him to return to surgery. But above all, no matter what department he works in, Ali has a lesson to learn about life.

Ali is trying to get used to pathology, albeit difficult. The worst thing is; Nazli will no longer help her return to surgery. Meanwhile, the entire surgical team mobilizes for a patient with an extraordinarily large tumor. But it seems impossible to remove the tumor without killing the man. Beliz, on the other hand, has a terrible suspicion about her friend who has just given birth. Standing on the edge of both cases, Ali has to do it on his own and do something he's never done before if he's going to return to surgery.

The moment of decision has come for Nazli. A delegation appointed by the ministry comes to the hospital to investigate the patient, whom he caused his death by wrong intubation on the night of the emergency. Adil's efforts to protect Nazli quickly fail.

Slowly making progress, Ali now has a big obstacle in front of him; With Adil's support, Ali finally decided to touch someone. But this task is definitely not as easy as it seems.

Ali, who learns Ferman's secret and gets closer to him than anyone else, thinks he has found his new brother. But Ferman asks him to keep everything he learned to himself. Not telling the truth is already a difficult task for Ali; On top of that, when Nazlı and Adil question him about what happened between him and Ferman, the situation becomes more difficult.

A lurking danger awaits Ali on prom night, and it is impossible for him to get over it without Ali's scalpel.

After dancing with Ali on prom night, Nazli finally has to confront her feelings for him.

With the love tactics he got from Demir, Ali tries to attack Nazlı for the first time, but this backfires badly. On the other hand, Beliz, who is on good terms with Ferman, decides to use the proceeds of the donation night for a charity. When Kıvılcım opposes this, the battle for control of the hospital begins all over again.

In the case of the Twins, all hope is lost and the team is faced with a terrible choice: For one brother to live, the other must die. But which one? Who can make this fatal decision?

Because of a secret, Betus's surgery cannot be performed and Adil has to convene a committee. Meanwhile, a man who was seriously injured while trying to act as a hero comes to the emergency room. But a procedure to prevent the man from becoming crippled has yet to be invented. Ferman still does not give up and starts a race between the assistants.

When the passengers of a plane returning from abroad start to get sick, the hospital is forced to take extreme measures. But people continue to die and, as a last resort, the emergency room is quarantined with all the people in it. Ferman, Ali and Nazli are also trapped inside. On the one hand, the team tries to provide health services to those who are inside, and on the other hand, tries to fight the epidemic. And in the end, one of the team also gets sick.

In the emergency, things are about to get out of control. Finally, one of the crew can't take it anymore and rushes in to help. Some control is achieved, but the danger has not yet been overcome. While Ferman's condition continues to worsen, the team, which does not have sufficient facilities inside, asks for the help of the patient's relatives. Everyone will have to do their best to survive the epidemic. As if all of this wasn't enough, on top of that, a birth begins in the emergency room...

Nazli and Ali decide to stay friends, but it is not as easy as it seems. When the two disagree on the treatment of a patient, things get complicated.

The news that Beliz is preparing a surprise birthday for Ferman throws the whole hospital into a sweet chaos. Unable to figure out how to manage a relationship, Nazlı and Ali take care of two high school teenagers who met during chemotherapy and are madly in love with each other, and they find something of themselves in their love.

Giving their relationship a chance for the first time, Ali and Nazli discover that making it work will be much harder than it seems. Kıvılcım, who puts his plan into effect on the other side, corners Beliz. Meanwhile, it turns out that the only liver suitable for a child in need of an emergency liver transplant belongs to a convicted prisoner. And despite all the risks, they bring the dangerous prisoner to the hospital.

When Beliz, who decided to fight Kıvılcım, reopens the new clinic and gets a new assistant in the surgical department, the swords are drawn again and this time the fight escalates to the expulsion of two people.

Tanju claims that it is her relationship with Nazli that confuses Ali, and the hospital will not approve of this relationship if Ali makes another mistake. Ali and Nazli have to be more careful than ever. But despite all the warnings, Ali personalizes his case and tries to find a way to help his young patient more at the expense of setting himself on fire.

Ali, who finds his father, who throws him on the street, after years, has serious issues to face. But instead of confronting them, Ali becomes obsessed with an orphaned patient who died during the operation and does not give up on the job despite all the warnings. On the other hand, Nazlı, who has started her duty at the new clinic, has to work with Damla, whose sincerity she cannot believe.

For the first time, Damla and Nazli assume the responsibility of a patient together and they get into each other directly. Under the influence of a mysterious visitor on the other side, Ali decides to save his father despite everything. But no one welcomes this sudden change of decision. Backed into a corner, Ali reflects on his frustration with his father on the case they worked with Ferman. And spiritual brothers Ferman and Ali are on the verge of parting ways.