As McCall acclimates to civilian life, she is compelled to use her considerable resources to help Jewel, a teenager accused of murder and on the run from the criminals who framed her for the crime.

McCall's online ad leads her to a mother whose son has been kidnapped by a human trafficker and will be executed unless she steals confidential information from her FBI agent employer. Also, McCall enlists Aunt Vi to help uncover a secret Delilah is keeping from them both.

McCall endeavors to help an escaped prisoner wrongly accused of murder who is too distrustful of the justice system that failed him to accept her aid. Also, McCall worries when her daughter, Delilah, stops hanging out with a close friend, and Detective Dante's search for McCall takes an unexpected turn.

McCall investigates a community activist's staged suicide and uncovers a connection between his murder and his protests over local real estate development. Also, Delilah's driving lessons lead McCall and Aunt Vi to teach her an even bigger lesson regarding personal accountability.

Doing a favor for CIA Director Suri Nance goes awry for McCall when she tries to locate a missing British mathematician and finds herself embroiled in an international fight for a revolutionary financial technology.

Mel goes undercover as a volunteer for a rising politician when McCall tries to help a despondent college student being threatened by someone inside the candidate’s campaign. Also, McCall worries when Delilah starts hanging out with a young girl who served time in juvenile detention and reminds McCall of her own troubled youth

McCall races to find a woman kidnapped by a serial killer whose past crimes went undetected because the victims were from marginalized communities. Also, trouble arises for McCall when her vigilante activity puts her on Manhattan District Attorney Avery Grafton's radar.

An overseas call for help from the daughter of McCall's deceased CIA mentor forces McCall, Mel and Harry to work remotely to aid the conflict journalist as she's pursued by a hit squad in France. Also, Aunt Vi becomes suspicious when McCall skips out on another family night for work.

McCall races to help a concerned wife locate her husband before he helps an extremist group carry out an imminent bombing in the city. Also, McCall worries that her anonymity will be compromised when Delilah asks her to participate in a mother/daughter social media video.

McCall’s personal and professional lives collide when Delilah and her friends are threatened by a European crime syndicate for being eyewitnesses to the outfit’s execution of a drug cartel boss.