In the premiere of an eight-part documentary series following the staff and patients at New York-Presbyterian Hospital, Dr. Mehmet Oz arranges a reunion between a patient and his ex-wife. Meanwhile, a woman with a brain tumor undergoes a risky surgery; an ER nurse fields romantic overtures from the people she treats; and two residents bond over their differences from their colleagues.

A man with a liver disease needs a transplant and hopes to live long enough for his daughter's wedding; a trauma surgeon finds his groove in New York after leaving New Orleans in the aftermath of Hurricane Katrina; ER nurses deal with demanding patients, including an intoxicated man who has to be subdued by security guards.

A woman with cystic fibrosis needs new lungs; an ER nurse makes a startling personal decision after hearing an elderly couple's story about their 65-year marriage; surgical residents share tales of hazing by senior surgeons.

An undocumented immigrant turned trauma surgeon treats a male who has been ingesting metallic objects. An old-school surgeon makes up for his lack of bedside manner with his skills in the operating room. A pediatric surgeon discusses the complicated and dangerous procedure of removing a tumor from the heart of a 4 year old girl.

A veteran of the Gulf War patiently waits for a donor heart. A serious of violent crimes keeps a surgical resident busy on a Friday night. Dr. Mehmet Oz preps for a colonoscopy, but isn't too busy to quiz his colleagues about their dietary habits.

A single mother with breast cancer finds out if her disease has spread; a surgical resident gets marital advice from a colleague; a first-year emergency-medicine resident's even temper helps him deal with inebriated patients and treat a woman that was in a car accident, but his self-control abandons him during a prank by his coworkers.

A collegiate swimmer whose arm was injured in a car accident requires a delicate surgery; a trauma surgeon counsels the family of a man who was run over by a car; a pediatric surgeon operates on a newborn; an ER doctor treats a woman with a life-threatening condition and is serenaded by a patient who needs stitches in his hand.

In the season finale, a banker and mother undergoes a risky cancer operation known as ex vivo; a cardiac surgeon realizes the unpredictability of a career in medicine; and an ER nurse is wooed by a dwarf stripper who was hurt while performing at a party, and whose cheating ex's best friend is a patient with a leg injury.