In the series premiere, Mighty Planes joins the crew of the worlds only flying eye hospital for their most challenging mission to date. Orbis travels tirelessly around the globe, offering patients in developing countries precious sight-saving treatments. On the outside, it's a regular DC-10. On the inside, it has been stripped and re-designed to house a state-of-the-art ophthalmic hospital complete with an operating room, a laser treatment facility and a high-tech classroom from which student doctors in host countries can watch surgeries live on 54 video screens.

In 2011, northern Mexico experienced its worst fire season in more than a century. Luckily, Martin Mars, the world's biggest seaplane was there to battle the blaze! Martin Mars has a partner in firefighting - the Sikorsky S76 - which uses HD and infrared cameras, along with state-of-the-art laser technology, to guide the Canadian owned and operated aircraft to a guaranteed bulls-eye with every drop. MIGHTY PLANES joins the four-person aerial crew when they answer the call for help as Mexico's northern states endure countless wildfires that threaten to destroy vast expanses of wilderness.

A revolution in aircraft design, the Airbus A380 is the word's largest passenger airliner. With room for more than 500 passengers, a tail as high as an eight-story building, and a wingspan nearly the length of a football field, this massive commercial airliner is a game changer. But it's also a big gamble for Lufthansa. Take flight on this mighty plane's maiden journey from Frankfurt, Germany to San Francisco, California as they try to win over customers and maximize profits. If the flight is successful, this Airbus may force other airlines to go big or go home.

The Hercules Skibird is the go-to aircraft for tough jobs in frozen places, and it's just 48 hours away from one of its most challenging missions yet. Follow this mighty plane and its dedicated crew to the top of the world as they prepare to evacuate climate scientists from Greenland's icy terrain. This mission will push the team and their powerful cargo plane to the limit as they attempt to fly, land, and take off in a country that holds the record for the worst flying conditions on the planet.

Recently upgraded to "Super Galaxy" status, this heavy-lifting aircraft can fly non-stop to virtually anywhere in the world, delivering cargo too large and too urgent to be shipped any other way. Follow along with the U.S. Air Force onboard this mighty plane on a marathon mission to Bagram, Afghanistan, a 14-hour, 6,200-mile journey requiring dangerous mid-air refueling and a perilous landing in the heart of enemy territory.

The Antonov 124, one of the biggest cargo planes in the world, is on its way to earthquake-ravaged Chile to deliver a massive wind turbine. But before this mighty plane can come to the country's aid, it must first prove it can handle the assignment. Witness the obstacles the Antonov and its crew must overcome to complete this two-day, 7,500-mile mission, including extreme weather and an exhaustive inspection that could reveal flaws too costly to repair. For this massive plane, a pit stop could mean the end of the road and an incomplete mission.