Don and Mimi Galvin's dream of raising a picture-perfect family in Colorado Springs gets thwarted as their eldest son, Donald, begins to act strangely.

The family's home life gets thrown into turmoil when Donald is released from the hospital, forcing some to leave; Brian's rockstar dreams end in tragedy.

Fourteen-year-old Peter suffers from a psychotic breakdown after a family member dies; a family secret forces Mary into an unthinkable situation.

A major rift in the family arises when Mimi dies, causing the next generation to fear that they might develop schizophrenia too; scientists and researchers use the Galvins' DNA to try and find a cure for the disease.