The murder of Bryan Mills' sister launches him into a dangerous mission for revenge against cartel boss Carlos Mejia. A secret US intelligence agency covertly uses Bryan as bait to capture Mejia, and recruits Bryan to become a part of their team.

Bryan gets his first chance in the field but the mission goes bust, resulting in a tragic death. The team uncovers a group of government officials skimming off of refugee funds, which also leads Christina to reconnect with a long lost love. Meanwhile, Asha shows up unexpectedly at Bryan's doorstep.

Bryan and team search for a suspected terrorist who has been taken, leading them to uncover a deeper plot within their own government. Christina receives troubling news and turns to Harry for support. Asha expresses her concern over Bryan's fixation with Mejia.

Riley's insistence to uncover the truth behind a fatal drug given to war vets results in her asset's child being taken. Bryan defies orders to rescue the girl and uncover the truth. When a break-in at Asha's apartment leaves her shaken, a new neighbor is there to calm her nerves.

Christina orders the retrieval of sensitive documents in Zurich needed to prevent economic and political disaster. But the mission to break into a bank vault turns into a three-way battle, and a race to escape safely. Meanwhile, Asha's trust in Elena proves to be misplaced and leaves Bryan vulnerable.

The ODNI are tasked with helping a Russian FSB agent defect, but the agent's pregnant girlfriend creates a problem for their plans. Meanwhile, Christina searches for a mole in the CIA and John faces a spiritual crisis after trying to resolve his brother's problem with a local gang.

Bryan is taken during the team's efforts to thwart a Mejia weapons operation; Bryan and Asha take the next step in their relationship.

The ODNI assist an Israeli spy with early onset Alzheimer's when her own agency tries to kill her. Also: Christina worries she may face a similar fate as she is threatened by forces within her own organization and Bryan and Asha have an argument due to Bryan's trust issues.

ODNI is forced to deliver a hostage to the FBI, but plans to hijack the transfer surface from the cartel. Later: John and Rem try to stall the handover; Bryan tries to keep the hostage in his custody; and Asha learns true identity of her best friend.

In the season finale, the FBI threatens to remove Christina from command and Bryan and John lead a rogue mission that risks everything to stop Mejia's associates before they cross the border.