Brigitte Nielsen, Joanie "Chyna Doll" Laurer, Jeff Conaway, Daniel Baldwin, Seth "Shifty" Binzer, Mary Carey, Jaimee Foxworth & Jessica Sierra, all "celebs" in their own right, check into rehab for care with Dr. Drew. While analyzing and accessing each paient, Dr. Drew is pulled away when Jeff Conaway laps into a drunken and doped up seizure.

Seth faces a struggle as he tries to cleanse the opiates from his body. Also, Jessica confronts the issues she had with her late mother. Later, Jeff returns to the hospital, but he still shows signs of substance withdrawal.

While some of the celeb patients are going along nicely with the program, others battle Dr. Drew and his staff. The subject of detoxing is discussed in the group meeting.

The patients talk about childhood trauma and other sources of pain which may have contributed to their addictions, as group therapy begins.

An emotionally charged group-therapy session has the patients showing some progress.

The patients are offered the choice of staying or being discharged from the facility. Meanwhile, the family of the celebrities join in the group therapy sessions while there for a visit.

Having revealed their problems to their loved ones, some group members believe the session was a success, while others find it necessary to check themselves out of the facility.

The celebrities try to test their newfound ability to cope concerning personal matters in the Outbound Program as they near the end of their stay in rehab. The final results will be assessed when they return home with their families.

In the conclusion of the first series, the celebrities and Dr. Drew recap the experiences from their stay and prepare for their release and trip home.

The cast of celebrities regroup to discuss their experiences at the rehab.