Luke travels deep into remote India where he has to face animals with extreme and life-threatening situations. From removing 14kg of plastic from a cows stomach to facing a dilemma with a two-legged dog, Luke pushes codes of the locals with new ideas.

Luke visits the Caribbean adventures take him island hopping to help wild and domestic animals, including a sea turtle caught in a fisherman's net. One of his patients requires an unusual operation and Luke discovers a new use for buttons!

Luke visits a country with hardly any vets where he faces the challenges of saving a starved dog with a new litter of pups, anesthetizing a leopard, and tracking in the bush, where he meets a troop of over familiar baboons!

Luke rides into the Mexican mountains with cowboys. He rescues a donkey from a swamp and races the clock to find out why a farmer's animals are suddenly dying. After working with a shelter, Luke checks on birds of prey and experiences flying like one.

Luke goes to stop the illegal practice of selling puppies on the streets. Helps an abused baboon, a pack of lions, finds the sex of infant cats and tests monkeys for tuberculosis. He investigates the death of buffaloes, and visits an elephant orphanage.

Luke travels to the Amazonian rainforest to assist vets from his own charity at a volunteer dog clinic. On the outskirts of town, he encounters the endangered Amazonian manatee. He ventures down the Amazon river to treat monkeys, macaws, and buffaloes.

Luke goes to work helping neglected equine and battling an STD blighting many street dogs. After a visit with an injured steppe eagle, he heads up the mountain to help an isolated community, where he gets his hands on some hairy yaks.

Luke is outside his comfort zone as he travels the Central American rainforests helping a host of different animals. Luke must pass a local surgical exam before he is allowed to operate on castaway dogs.

In this final episode, Luke sets off to see some of the world's most endangered animals. He follows the rehabilitation of cheeky chimps and tracks white rhinos. Luke fulfills a boyhood dream of tracking the mountain gorilla in Bwindi Impenetrable Forest.