Chicago EMT’s and longtime best friends Johnny and Hank are breaking in Brian, an eager new recruit. Johnny’s on again-off again relationship with Theresa, a cop with Chicago PD, is the main topic of the day. Hank implores him to move on, especially when he sees Theresa flirt with her new partner Danny, who Hank calls a dead ringer for Denzel Washington. But Johnny’s not ready to let go, even though it was his inability to commit that drove Theresa away. And when he finds out that she has a date that very night, he enlists Hank and a reluctant Brian to help him with a stakeout.

A lightning strike at a church picnic gets the guys to start thinking about how there’s no justice in sickness and injury, because like it or not, the “rain falls equally on the just and the unjust.” After a discussion of karma, the guys volunteer to teach CPR to disadvantaged kids only to later be given killer Bears tickets for the same day they’re supposed to teach.

A patient knocking on death's door pleads with the guys to go back to his house and clear the search history on his computer. After they stumble across a troubling image on the computer screen, the guys can’t get it out of their heads. Meanwhile, Johnny remembers that Theresa has his iPad and it contains things that he wishes he could clear.

A dying man’s last words inspire Johnny to have the first conversation he’s had with his dad in seven years. Elsewhere, a determined Brian takes Hank on a quest to communicate the dead man’s final message to a long lost love.

After a drunken hook up, Johnny and Theresa decide they can have "just sex" so long as they establish clear ground rules. Meanwhile, the guys treat injuries resulting from a drunken backyard game of illegal "Jarts", one of which allows Brian to start checking items off his EMT “bucket list.”

Johnny introduces Theresa to his father and is taken aback when his Dad drops a bomb of a secret on him. Elsewhere, Brian struggles to find the right moves to put on his work crush, while Hank gets a new father figure that he never planned for.

Johnny steps up for his friend when Hank gets an invitation to his Ex’s wedding, while Theresa has trouble seeing eye to eye with a wedding guest. Meanwhile, Brian learns a new job skill.

After it's revealed that Hank is deathly afraid of spiders and Brian comes face-to-face with his suicidal doppleganger, everyone examines their own fears, and Johnny gets payback for all the practical jokes he’s played.

While teaching a class to prospective EMTs, the crew recalls a day that ran the gamut from the mundane to the catastrophic, and Johnny tries to find out who ate last the donut.

Theresa has a brush with death on the job and resolves to join the FBI in Washington. When Johnny proposes marriage to keep her in Chicago, they must overcome a series of catastrophes and mishaps to get to the altar.