Paul and Terry take their surgical expertise on the road. In the series premiere, the doctors help a young woman with deformed breasts, and a twin born with facial abnormalities.

The doctors travel to Texas to meet a female war veteran that was struck by lightning leaving her breasts and body disfigured. Then, Dr. Nassif sympathizes with a South Carolina woman who has a misplaced toe on each foot.

The Doctors travel to Iowa to see a young father whose infected chest implant is threatening his life. Then, they meet a pair of twins with matching cleft deformities who want to look more identical.

The doctors head to Louisiana to meet with a man whose nasal syndrome has him tired of facing the public. In California they meet with a woman who was born with a conjoined twin.

Doctors Dubrow and Nassif travel to Virginia to meet a young woman with severely deformed breasts. Later, Paul discovers he has a serious medical condition.

The doctors meet a young mother born with Pectus Excavatum. They also consult with a woman born pre-maturely whose nasal complications grew with her into adulthood.

The doctors head to Arizona to help a woman whose nose collapsed into her own face. In NYC, they meet a college student with an oversized breast, and later check up on Tiffany Pollard.

The doctors visit a young mother in Detroit whose breasts never developed normal tissue. In Atlanta they see a woman who has overgrown tissue in her mouth and check in with Dwight Eubanks.