A man is treated for gunshot wounds in the opener of this series following emergency responders working the night shift in New Orleans.

It’s an emotional night on the Nightwatch in New Orleans as one EMS officer tells his partner that this is their last night on the job. Meanwhile, it’s a tough night in a different way for the fire fighters as the group responds to a call about a truck on fire after a collision at a gas station. It’s a night that serves as a reminder that the people of the Nightwatch aren’t just there for their city–they’re there for each other.

The heavy response to an officer's shooting leaves emergency medical technicians in an agonizing wait for police backup; firefighters work to extinguish a flaming car.

Firefighters battle a blaze; police officers search for a burglary suspect.

Police officers Victor and Lejon join a SWAT team operation hunting a homicide suspect. The fire department tries to save a man who fell in the Mississippi River. For the EMTs, the calls tonight are as much about comforting victims as they are about saving them.

Crazy calls abound on the night of a full moon; two fleet-footed police officers run down suspects.

Justin and Randy pursue a suspected car thief; both EMT teams race to help children in distress.

Suspected drug dealers are hunted by the police; a violent schizophrenic threatens a group of partygoers.

Police and EMS teams in New Orleans deal with armed robberies and shootings on New Year's Eve; Gavin returns to work.